Format

Send to

Choose Destination
Proc Natl Acad Sci U S A. 2019 Apr 30;116(18):9078-9083. doi: 10.1073/pnas.1900390116. Epub 2019 Apr 12.

Reduced default mode network functional connectivity in patients with recurrent major depressive disorder.

Yan CG1,2,3,4, Chen X5,2, Li L5,2, Castellanos FX4,6, Bai TJ7, Bo QJ8, Cao J9, Chen GM10, Chen NX5,2, Chen W11, Cheng C12, Cheng YQ13, Cui XL12, Duan J14, Fang YR15, Gong QY16,17, Guo WB12, Hou ZH18, Hu L9, Kuang L9, Li F8, Li KM16, Li T19, Liu YS20, Liu ZN12, Long YC12, Luo QH9, Meng HQ9, Peng DH15, Qiu HT9, Qiu J21, Shen YD22, Shi YS23, Wang CY8, Wang F14, Wang K7, Wang L24,25, Wang X12, Wang Y10, Wu XP26, Wu XR21, Xie CM27, Xie GR12, Xie HY28, Xie P29,30,31, Xu XF13, Yang H23, Yang J32, Yao JS11, Yao SQ12, Yin YY18, Yuan YG18, Zhang AX32, Zhang H26, Zhang KR33, Zhang L5,2, Zhang ZJ27, Zhou RB15, Zhou YT19, Zhu JJ15, Zou CJ13, Si TM24,25, Zuo XN5,2,3, Zhao JP34, Zang YF35,36.

Author information

1
Key Laboratory of Behavioral Science, Institute of Psychology, Chinese Academy of Sciences, Beijing 100101, China; ycg.yan@gmail.com zhaojingping@csu.edu.cn zangyf@hznu.edu.cn.
2
Department of Psychology, University of Chinese Academy of Sciences, Beijing 100049, China.
3
Magnetic Resonance Imaging Research Center and Research Center for Lifespan Development of Mind and Brain, Institute of Psychology, Chinese Academy of Sciences, Beijing 100101, China.
4
Department of Child and Adolescent Psychiatry, New York University School of Medicine, New York, NY 10016.
5
Key Laboratory of Behavioral Science, Institute of Psychology, Chinese Academy of Sciences, Beijing 100101, China.
6
Nathan Kline Institute for Psychiatric Research, Orangeburg, NY 10962.
7
Anhui Medical University, Hefei, Anhui 230022, China.
8
Beijing Anding Hospital, Capital Medical University, Beijing 100054, China.
9
Department of Psychiatry, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
10
The First Affiliated Hospital of Jinan University, Guangzhou, Guangdong 510630, China.
11
Department of Psychiatry, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310016, China.
12
Department of Psychiatry, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, China.
13
First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650032, China.
14
Department of Psychiatry, First Affiliated Hospital, China Medical University, Shenyang, Liaoning 110001, China.
15
Department of Psychiatry, Shanghai Jiao Tong University School of Medicine, Shanghai 200240, China.
16
Department of Radiology, Huaxi MR Research Center, West China Hospital of Sichuan University, Chengdu, Sichuan 610041, China.
17
Psychoradiology Research Unit of Chinese Academy of Medical Sciences, West China Hospital of Sichuan University, Chengdu, Sichuan 610041, China.
18
Department of Psychosomatics and Psychiatry, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu 210096, China.
19
Mental Health Center, West China Hospital, Sichuan University Chengdu, Sichuan 610041, China.
20
Department of Clinical Psychology, Suzhou Psychiatric Hospital, The Affiliated Guangji Hospital of Soochow University, Suzhou, Jiangsu 215137, China.
21
Faculty of Psychology, Southwest University, Chongqing 400716, China.
22
Department of Diagnostics, Affiliated Hospital, School of Medicine, Hangzhou Normal University, Hangzhou, Zhejiang 311121, China.
23
Department of Radiology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang 310058, China.
24
National Clinical Research Center for Mental Disorders, Peking University Sixth Hospital, Beijing 100191, China.
25
Key Laboratory of Mental Health, Ministry of Health, Peking University, Beijing 100191, China.
26
Xi'an Central Hospital, Xi'an, Shaanxi 710003, China.
27
Department of Neurology, Affiliated ZhongDa Hospital of Southeast University, Nanjing, Jiangsu 210009, China.
28
Department of Psychiatry, The Fourth Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang 310058, China.
29
Institute of Neuroscience, Chongqing Medical University, Chongqing 400016, China.
30
Chongqing Key Laboratory of Neurobiology, Chongqing 400016, China.
31
Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
32
The First Affiliated Hospital of Xi'an Jiaotong University, Shaanxi 710061, China.
33
First Hospital of Shanxi Medical University, Taiyuan, Shanxi 030001, China.
34
Department of Psychiatry, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, China; ycg.yan@gmail.com zhaojingping@csu.edu.cn zangyf@hznu.edu.cn.
35
Center for Cognition and Brain Disorders, Institutes of Psychological Sciences, Hangzhou Normal University, Hangzhou, Zhejiang 311121, China; ycg.yan@gmail.com zhaojingping@csu.edu.cn zangyf@hznu.edu.cn.
36
Zhejiang Key Laboratory for Research in Assessment of Cognitive Impairments, Hangzhou, Zhejiang 311121, China.

Abstract

Major depressive disorder (MDD) is common and disabling, but its neuropathophysiology remains unclear. Most studies of functional brain networks in MDD have had limited statistical power and data analysis approaches have varied widely. The REST-meta-MDD Project of resting-state fMRI (R-fMRI) addresses these issues. Twenty-five research groups in China established the REST-meta-MDD Consortium by contributing R-fMRI data from 1,300 patients with MDD and 1,128 normal controls (NCs). Data were preprocessed locally with a standardized protocol before aggregated group analyses. We focused on functional connectivity (FC) within the default mode network (DMN), frequently reported to be increased in MDD. Instead, we found decreased DMN FC when we compared 848 patients with MDD to 794 NCs from 17 sites after data exclusion. We found FC reduction only in recurrent MDD, not in first-episode drug-naïve MDD. Decreased DMN FC was associated with medication usage but not with MDD duration. DMN FC was also positively related to symptom severity but only in recurrent MDD. Exploratory analyses also revealed alterations in FC of visual, sensory-motor, and dorsal attention networks in MDD. We confirmed the key role of DMN in MDD but found reduced rather than increased FC within the DMN. Future studies should test whether decreased DMN FC mediates response to treatment. All R-fMRI indices of data contributed by the REST-meta-MDD consortium are being shared publicly via the R-fMRI Maps Project.

KEYWORDS:

REST-meta-MDD; default mode network; functional connectivity; major depressive disorder; resting-state fMRI

Supplemental Content

Full text links

Icon for HighWire Icon for PubMed Central
Loading ...
Support Center