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Nutrients. 2019 Apr 11;11(4). pii: E820. doi: 10.3390/nu11040820.

Effects of Lactobacillus plantarum PS128 on Children with Autism Spectrum Disorder in Taiwan: A Randomized, Double-Blind, Placebo-Controlled Trial.

Author information

1
Institute of Biochemistry and Molecular Biology, National Yang-Ming University, Taipei 11221, Taiwan. skywenn@gmail.com.
2
Microbiome Research Center, National Yang-Ming University, Taipei 11221, Taiwan. skywenn@gmail.com.
3
School of Industrial Technology, Universiti Sains Malaysia, Penang 11800, Malaysia. mintze.liong@usm.my.
4
Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei 10050, Taiwan. eesabella1126@gmail.com.
5
Department of Psychology, National Taiwan University, Taipei 10090, Taiwan. huanghuyiii@gmail.com.
6
Institute of Biochemistry and Molecular Biology, National Yang-Ming University, Taipei 11221, Taiwan. catpet1022@hotmail.com.
7
Institute of Biochemistry and Molecular Biology, National Yang-Ming University, Taipei 11221, Taiwan. hiyunfang@gmail.com.
8
Department of Psychology, National Chengchi University, Taipei 11605, Taiwan. linyusiou@gmail.com.
9
YuNing Clinic, Taipei 10664, Taiwan. ruthyuyuwu@gmail.com.
10
Institute of Biochemistry and Molecular Biology, National Yang-Ming University, Taipei 11221, Taiwan. tsaiyc@ym.edu.tw.
11
Microbiome Research Center, National Yang-Ming University, Taipei 11221, Taiwan. tsaiyc@ym.edu.tw.

Abstract

This four-week, randomized, double-blind, placebo-controlled study investigated the effects of Lactobacillus plantarum PS128 (PS128) on boys with autism spectrum disorder (ASD) aged 7-15 in Taiwan. All subjects fulfilled the criteria for ASD diagnosis of DSM-V and the Autism Diagnostic Interview-Revised (ADI-R). Questionnaires used for the primary outcome measure include the Autism Behavior Checklist-Taiwan version (ABC-T), the Social Responsiveness Scale (SRS) and the Child Behavior Checklist (CBCL). The Swanson, Nolan, and Pelham-IV-Taiwan version (SNAP-IV) and the Clinical Global Impression-improvement (CGI-I) were used for the secondary outcome measure. The results showed that PS128 ameliorated opposition/defiance behaviors, and that the total score of SNAP-IV for younger children (aged 712) improved significantly compared with the placebo group. Additionally, several elements were also notably improved in the PS128 group after 28-day consumption of PS128. Further studies are needed to better clarify the effects of PS128 for younger children with ASD on broader symptoms.

KEYWORDS:

Lactobacillus plantarum PS128; anxiety; autism spectrum disorder (ASD); hyperactivity; psychobiotic

PMID:
30979038
PMCID:
PMC6521002
DOI:
10.3390/nu11040820
[Indexed for MEDLINE]
Free PMC Article

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