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J Clin Med. 2019 Apr 11;8(4). pii: E488. doi: 10.3390/jcm8040488.

Effectiveness of Creatine Supplementation on Aging Muscle and Bone: Focus on Falls Prevention and Inflammation.

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Faculty of Kinesiology and Health Studies, University of Regina, Regina, SK S4S 0A2, Canada.
Department of Physical Education, Brandon University, Brandon, MB R7A 6A9, Canada. ForbesS@BrandonU.CA.
College of Kinesiology, University of Saskatchewan, Saskatoon, SK S7N 5B2, Canada.
Faculty of Kinesiology and Recreation Management, University of Manitoba, Winnipeg, MB R3T 2N2, Canada.
Department of Health and Human Performance, Nova Southeastern University, Davie, FL 33314, USA.
Department of Health and Kinesiology, Texas A&M University, College Station, TX 77843-4253, USA.


Sarcopenia, defined as the age-related decrease in muscle mass, strength and physical performance, is associated with reduced bone mass and elevated low-grade inflammation. From a healthy aging perspective, interventions which overcome sarcopenia are clinically relevant. Accumulating evidence suggests that exogenous creatine supplementation has the potential to increase aging muscle mass, muscle performance, and decrease the risk of falls and possibly attenuate inflammation and loss of bone mineral. Therefore, the purpose of this review is to: (1) summarize the effects of creatine supplementation, with and without resistance training, in aging adults and discuss possible mechanisms of action, (2) examine the effects of creatine on bone biology and risk of falls, (3) evaluate the potential anti-inflammatory effects of creatine and (4) determine the safety of creatine supplementation in aging adults.


dynapenia; exercise; functionality; mechanisms; safety; sarcopenia

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