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PLoS One. 2019 Apr 12;14(4):e0214523. doi: 10.1371/journal.pone.0214523. eCollection 2019.

Integration of heterogeneous functional genomics data in gerontology research to find genes and pathway underlying aging across species.

Author information

1
The Jackson Laboratory, Bar Harbor ME, United States of America.
2
The University of Arizona, Molecular and Cellular Biology, United States of America.
3
Baylor University, Waco, TX, United States of America.
4
The Jackson Laboratory Nathan Shock Center of Excellence in the Basic Biology of Aging, The Jackson Laboratory, Bar Harbor, ME, United States of America.
5
University of Tennessee Knoxville, Knoxville, TN, United States of America.

Abstract

Understanding the biological mechanisms behind aging, lifespan and healthspan is becoming increasingly important as the proportion of the world's population over the age of 65 grows, along with the cost and complexity of their care. BigData oriented approaches and analysis methods enable current and future bio-gerontologists to synthesize, distill and interpret vast, heterogeneous data from functional genomics studies of aging. GeneWeaver is an analysis system for integration of data that allows investigators to store, search, and analyze immense amounts of data including user-submitted experimental data, data from primary publications, and data in other databases. Aging related genome-wide gene sets from primary publications were curated into this system in concert with data from other model-organism and aging-specific databases, and applied to several questions in genrontology using. For example, we identified Cd63 as a frequently represented gene among aging-related genome-wide results. To evaluate the role of Cd63 in aging, we performed RNAi knockdown of the C. elegans ortholog, tsp-7, demonstrating that this manipulation is capable of extending lifespan. The tools in GeneWeaver enable aging researchers to make new discoveries into the associations between the genes, normal biological processes, and diseases that affect aging, healthspan, and lifespan.

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