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PLoS Comput Biol. 2019 Apr 12;15(4):e1006969. doi: 10.1371/journal.pcbi.1006969. eCollection 2019 Apr.

A global map of the protein shape universe.

Author information

1
Department of Biological Sciences, Purdue University, West Lafayette, Indiana, United States of America.
2
Department of Mathematics & Statistics, Eastern Kentucky University, Richmond, Kentucky, United States of America.
3
Department of Computer Science, Purdue University, West Lafayette, Indiana, United States of America.

Abstract

Proteins are involved in almost all functions in a living cell, and functions of proteins are realized by their tertiary structures. Obtaining a global perspective of the variety and distribution of protein structures lays a foundation for our understanding of the building principle of protein structures. In light of the rapid accumulation of low-resolution structure data from electron tomography and cryo-electron microscopy, here we map and classify three-dimensional (3D) surface shapes of proteins into a similarity space. Surface shapes of proteins were represented with 3D Zernike descriptors, mathematical moment-based invariants, which have previously been demonstrated effective for biomolecular structure similarity search. In addition to single chains of proteins, we have also analyzed the shape space occupied by protein complexes. From the mapping, we have obtained various new insights into the relationship between shapes, main-chain folds, and complex formation. The unique view obtained from shape mapping opens up new ways to understand design principles, functions, and evolution of proteins.

PMID:
30978181
PMCID:
PMC6481876
DOI:
10.1371/journal.pcbi.1006969
[Indexed for MEDLINE]
Free PMC Article

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