Send to

Choose Destination
Alcohol Clin Exp Res. 2019 Jun;43(6):1170-1179. doi: 10.1111/acer.14048. Epub 2019 May 6.

Alterations in White Matter Microstructure and Connectivity in Young Adults with Alcohol Use Disorder.

Author information

Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, Indiana.
Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, Indiana.
Medical Scientist Training Program, Indiana University School of Medicine, Indianapolis, Indiana.
Department of Neurology, Indiana University School of Medicine, Indianapolis, Indiana.
Department of Psychological and Brain Sciences, Indiana University, Bloomington, Indiana.
Program in Neuroscience, Indiana University, Bloomington, Indiana.
Department of Psychology, Indiana University-Purdue University Indianapolis, Indianapolis, Indiana.



Magnetic resonance imaging (MRI) studies have shown differences in volume and structure in the brains of individuals with alcohol use disorder (AUD). Most research has focused on neuropathological effects of alcohol that appear after years of chronic alcohol misuse. However, few studies have investigated white matter (WM) microstructure and diffusion MRI-based (DWI) connectivity during early stages of AUD. Therefore, the goal of this work was to investigate WM integrity and structural connectivity in emerging adulthood AUD subjects using both conventional DWI metrics and a novel connectomics approach.


Twenty-two AUD and 18 controls (CON) underwent anatomic and diffusion MRI. Outcome measures were scalar diffusion metrics and structural network connectomes. Tract-Based Spatial Statistics was used to investigate group differences in diffusion measures. Structural connectomes were used as input into a community structure procedure to obtain a coclassification index matrix (an indicator of community association strength) for each subject. Differences in coclassification and structural connectivity (indexed by streamline density) were assessed via the Network Based Statistics Toolbox.


AUD had higher fractional anisotropy (FA) values throughout the major WM tracts, but also had lower FA values in WM tracts in the cerebellum and right insula (pTFCE  < 0.05). Mean diffusivity was generally lower in the AUD group (pTFCE  < 0.05). AUD had lower coclassification of nodes between ventral attention and default mode networks and higher coclassification between nodes of visual, default mode, and somatomotor networks. Additionally, AUD had higher fiber density between an adjacent pair of nodes within the default mode network.


Our results indicate that emerging adulthood AUD subjects may have differential patterns of FA and distinct differences in structural connectomes compared with CON. These data suggest that such alterations in microstructure and structural connectivity may uniquely characterize early stages of AUD and/or a predisposition for development of AUD.


Alcohol Use Disorder; Connectivity; DTI; Neuroimaging; White Matter

[Available on 2020-06-01]

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center