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Ocul Oncol Pathol. 2019 Feb;5(2):147-152. doi: 10.1159/000491381. Epub 2018 Aug 27.

Primary Cutaneous Follicle Center Lymphoma of the Eyelid: A Case Report and Review of the Literature in Light of Recent Changes to the WHO Classification of Lymphoid Neoplasms.

Author information

1
Tufts Medical Center - New England Eye Center, Boston, Massachusetts, USA.
2
Hackensack University Medical Center, Hackensack, New Jersey, USA.

Abstract

Primary cutaneous follicle center lymphoma (PCFCL) is a unique entity that represents up to 11% of all cutaneous lymphomas. PCFCL is associated with an indolent course and excellent 5-year survival rates, but can progress to secondary systemic involvement if left untreated. Histopathologic features of PCFCL can vary depending on the size, duration, and clinical stage of the lesion, making diagnosis somewhat challenging. Here, we present a case of a 50-year-old woman with an eyelid lesion that was initially classified as an inflamed cyst based on biopsy, but 1 year later, was determined to be PCFCL after repeat biopsy revealed different histology. In light of the recent changes to the WHO classification of lymphoid neoplasms, we review the unique clinical and histopathologic features of PCFCL that distinguish it from other more aggressive forms of cutaneous lymphoma in terms of course, prognosis, and management.

KEYWORDS:

Eyelid; Histopathology; Immunophenotype; Lymphoma; Primary cutaneous follicle center lymphoma

PMID:
30976595
PMCID:
PMC6422136
[Available on 2020-02-01]
DOI:
10.1159/000491381

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