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Sci Rep. 2019 Apr 11;9(1):5954. doi: 10.1038/s41598-019-42355-y.

Genome Organization of Canada Goose Coronavirus, A Novel Species Identified in a Mass Die-off of Canada Geese.

Author information

1
National Centre for Foreign Animal Disease, Canadian Food Inspection Agency, Winnipeg, MB, Canada.
2
Department of Biological Sciences, University of Manitoba, Winnipeg, MB, Canada.
3
Department of Pediatrics, Washington University School of Medicine, St. Louis, St. Louis, MO, USA.
4
McDonnell Genome Institute, Washington University School of Medicine in St. Louis, St. Louis, MO, USA.
5
Faculty of Veterinary Medicine, University of Calgary, Calgary, AB, Canada.
6
National Centre for Foreign Animal Disease, Canadian Food Inspection Agency, Winnipeg, MB, Canada. Oliver.Lung@canada.ca.
7
Department of Biological Sciences, University of Manitoba, Winnipeg, MB, Canada. Oliver.Lung@canada.ca.

Abstract

The complete genome of a novel coronavirus was sequenced directly from the cloacal swab of a Canada goose that perished in a die-off of Canada and Snow geese in Cambridge Bay, Nunavut, Canada. Comparative genomics and phylogenetic analysis indicate it is a new species of Gammacoronavirus, as it falls below the threshold of 90% amino acid similarity in the protein domains used to demarcate Coronaviridae. Additional features that distinguish the genome of Canada goose coronavirus include 6 novel ORFs, a partial duplication of the 4 gene and a presumptive change in the proteolytic processing of polyproteins 1a and 1ab.

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