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Ann Clin Biochem. 2019 Apr 11:4563219835853. doi: 10.1177/0004563219835853. [Epub ahead of print]

Changes of iron metabolism during pregnancy and the establishment of reference intervals for pregnant Chinese women.

Author information

1
1 Department of Laboratory Medicine, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
2
2 Department of Blood Transfusion, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.

Abstract

BACKGROUND:

Abnormalities of iron metabolism in pregnancy pose risks for maternal and fetal health. Robust reference intervals for iron metabolism indices have not been established in a pregnant Chinese population. The purpose of this study was to derive reference intervals for indices of iron metabolism during pregnancy in a Chinese population.

METHODS:

A total of 360 healthy pregnant women were recruited and divided into three groups of 120 by gestational age: first trimester (1-13 weeks), second trimester (14-27 weeks) and third trimester (≥28 weeks). An additional 120 healthy non-pregnant women were recruited as the non-pregnant control group. Serum ferritin was measured by electrochemiluminescence immunoassay. Serum iron and total iron-binding capacity were measured by a direct bathophenanthroline method. Transferrin saturation value was calculated with formula TS = SI/TIBC. The reference intervals were established using a non-parametric method.

RESULTS:

In first and second trimesters (combined), the reference intervals for serum ferritin, serum iron, total iron-binding capacity and transferrin saturation are 14.7-184.3 mg/L, 14.50-33.45 µmol/L, 36.53-68.81 µmol/L and 19.04-64.76%, respectively. In the third trimester, the reference intervals for serum ferritin, serum iron, total iron-binding capacity and transferrin saturation are 7.2-122.2 mg/L, 5.83-21.52 µmol/L, 49.40-122.76 µmol/L and 8.22-52.75%, respectively.

CONCLUSION:

The reference intervals for iron metabolism indices for healthy pregnant Chinese women were established in accordance with CLSI C28-A3 guidelines. This will be a valuable tool for clinical practice and research.

KEYWORDS:

Iron disorders; pregnancy

PMID:
30974959
DOI:
10.1177/0004563219835853

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