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Int J Gynaecol Obstet. 2019 Apr 11. doi: 10.1002/ijgo.12822. [Epub ahead of print]

Prevalence of fibromyalgia among women with deep infiltrating endometriosis.

Author information

1
Department of Gynecology, Institut Clínic of Gynecology, Obstetrics and Neonatology, Hospital Clínic of Barcelona, Barcelona, Spain.
2
Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.
3
Faculty of Medicine, University of Barcelona, Barcelona, Spain.
4
Service of Rheumatology, Institut Clínic d'Especialitats Mèdiques i Quirúrgiques, Hospital Clínic of Barcelona, Barcelona, Spain.

Abstract

OBJECTIVE:

To estimate the prevalence of fibromyalgia among women with endometriosis and analyze the effect of fibromyalgia on health-related quality of life (HRQoL).

METHODS:

An observational case-control study conducted at a tertiary hospital in Barcelona between April 2015 and March 2017 among women with deep infiltrating endometriosis (DIE; n=80), women with superficial endometriosis or ovarian endometrioma (non-DIE; n=76), and control women without endometriosis (n=73). Fibromyalgia was assessed via the London Fibromyalgia Epidemiological Study Screening Questionnaire (LFESSQ). HRQoL was evaluated with the 36-Item Short Form (SF-36) questionnaire. The impact of fibromyalgia and other clinical characteristics was assessed by multivariate regression analysis.

RESULTS:

More women fulfilled the criteria for fibromyalgia in the DIE group than in the non-DIE and control groups by LFESSQ-4 (31 [39%], 12 [16%], and 6 [8%], respectively; P=0.009) and LFESSQ-6 (22 [28%], 8 [11%], and 4 [5%], respectively; P=0.008). The DIE group reported significantly poorer HRQoL for all SF-36 dimensions. Women with DIE who fulfilled the criteria for fibromyalgia had lower physical component scores (-31.6; 95% confidence interval, -50.8 to -12.3; P=0.003).

CONCLUSION:

The estimated prevalence of fibromyalgia was higher among women with DIE. Women with DIE and positive fibromyalgia screening had lower HRQoL.

KEYWORDS:

Deep infiltrating endometriosis; Endometriosis; Fibromyalgia; London Fibromyalgia Epidemiological Study Screening Questionnaire; Pain; Quality of life; SF-36 questionnaire

PMID:
30973964
DOI:
10.1002/ijgo.12822

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