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Biol Aujourdhui. 2018;212(3-4):55-59. doi: 10.1051/jbio/2018025. Epub 2019 Apr 11.

[Circadian proteomics].

[Article in French]

Author information

1
Institut de Bioingénierie, Faculté des Sciences de la Vie, École Polytechnique Fédérale de Lausanne, 1015 Lausanne, Suisse - Département de Pharmacologie et Toxicologie, Université de Lausanne, 1005 Lausanne, Suisse.

Abstract

Recent development in the proteomic technologies offers new perspectives in circadian biology and in particular the possibility to study post-translational modifications such as phosphorylation and acetylation. Applying in vivo proteomics on whole liver or on nuclear extracts, we were able to characterize the rhythmic liver proteome with unprecedented coverage. It allows the characterization of new rhythmic processes such as protein secretion, ribosome biogenesis, DNA repair, and polyploidy. In addition, the analysis of rhythmic post-translational modifications helps to understand the signal pathways involved and their consequences on hepatic metabolism.

PMID:
30973132
DOI:
10.1051/jbio/2018025

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