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Anticancer Agents Med Chem. 2019 Apr 11. doi: 10.2174/1871520619666190411121953. [Epub ahead of print]

Recent Developments of Nanoparticles In The Treatment Of Photodynamic Therapy For Cervical Cancer.

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Department of Radiation, Affiliated Hospital of Xuzhou Medical University, Xuzhou 221002, China
Department of Dermatology, Xinyi People's Hospital, Xuzhou 221002, China
Department of Dermatology, Affiliated Hospital of Xuzhou Medical University, Xuzhou 221002, China


Photodynamic therapy (PDT) is a photoactivation or photosensitization process, wherein the photosensitizer (PS) is activated under appropriate wavelengths. Conventional antitumor therapy for cervical cancer includes surgery, radiotherapy, and chemotherapy. However, these techniques are accompanied by some evident shortcomings. PDT is considered an emerging minimally invasive treatment for cervical cancer. In recent years, new PSs have been synthesized because of long absorption wavelength, good solubility, and high tumor targeting ability. Studies also showed that the synergistic combination of nanomaterials with PSs results in considerable benefits compared with the use of small-molecule PSs alone. The compounds can act both as a drug delivery system and PS and enhance the photodynamic effect. This review summarizes the application of some newly synthesized PSs and PS-combined nanoparticles in cervical cancer treatment to enhance the efficiency of PDT. The mechanism and influencing factors of PDT are further elaborated.


Photodynamic therapy; cervical cancer; drug delivery system; nanoparticle; photosensitizer; radiotherapy.

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