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Anal Bioanal Chem. 2019 Apr 10. doi: 10.1007/s00216-019-01756-8. [Epub ahead of print]

High-performance bioanalysis based on ion concentration polarization of micro-/nanofluidic devices.

Author information

1
State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, 210023, Jiangsu, China.
2
Key Laboratory of Biomedical Functional Materials, School of Science, China Pharmaceutical University, Nanjing, 211198, Jiangsu, China.
3
State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, 210023, Jiangsu, China. xhxia@nju.edu.cn.

Abstract

Micro-/nanofluidics has received considerable attention over the past two decades, which allows efficient biomolecule trapping and preconcentration due to ion concentration polarization (ICP) within nanostructures. The rich scientific content related to ICP has been widely exploited in different applications including protein concentration, biomolecules sensing and detection, cell analysis, and water purification. Compared to pure microfluidic devices, micro-/nanofluidic devices show a highly efficient sample enrichment capacity and nonlinear electrokinetic flow feature. These two unique characterizations make the micro-/nanofluidic systems promising in high-performance bioanalysis. This review provides a comprehensive description of the ICP phenomenon and its applications in bioanalysis. Perspectives are also provided for future developments and directions of this research field.

KEYWORDS:

Bioanalysis; Ionic concentration polarization (ICP); Micro-/nanofluidics; Nonlinear electrokinetic flow; Preconcentration

PMID:
30972474
DOI:
10.1007/s00216-019-01756-8

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