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Diagn Microbiol Infect Dis. 2019 Mar 13. pii: S0732-8893(19)30094-X. doi: 10.1016/j.diagmicrobio.2019.03.002. [Epub ahead of print]

Influenza B false-positive results by rapid molecular tests Alere™ i Influenza A&B 2 in France.

Author information

1
Service de microbiologie, Hôpital d'Instruction des Armées Sainte Anne, Toulon, France.
2
Service de biologie, C.H.I Toulon la Seyne sur mer, Toulon, France.
3
Service de microbiologie, Hôpital d'Instruction des Armées Sainte Anne, Toulon, France; Ecole du Val-de-Grâce, Paris, France. Electronic address: janvierfred@hotmail.com.

Abstract

The Alere-i™ Influenza A&B (Abbott), a nicking endonuclease amplification reaction test, has recently been improved in order to deliver results in a few minutes. Our field observation highlights two problems with this new version: improper interpretation of a test as valid despite improper reagent hydration and falsely influenza B positive results. We advise users of the new system to check reagent hydration prior to reporting a result and to systematically confirm positive influenza B results.

KEYWORDS:

Alere i a/B 2; False positive; Influenza; Rapid molecular tests

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