Format

Send to

Choose Destination
Cell Rep. 2019 Apr 9;27(2):514-524.e5. doi: 10.1016/j.celrep.2019.03.030.

Obesity Expands a Distinct Population of T Cells in Adipose Tissue and Increases Vulnerability to Infection.

Author information

1
Department of Genetics, UNC-Chapel Hill School of Medicine, Chapel Hill, NC, USA.
2
Department of Nutrition, UNC-Chapel Hill Gillings School of Global Public Health, Chapel Hill, NC, USA.
3
Department of Genetics, UNC-Chapel Hill School of Medicine, Chapel Hill, NC, USA; Department of Microbiology & Immunology, UNC-Chapel Hill School of Medicine, Chapel Hill, NC, USA. Electronic address: jwhitmir@email.unc.edu.

Abstract

Obesity in humans is associated with poorer health outcomes after infections compared with non-obese individuals. Here, we examined the effects of white adipose tissue and obesity on T cell responses to viral infection in mice. We show that lymphocytic choriomeningitis virus (LCMV) grows to high titer in adipose tissue. Virus-specific T cells enter the adipose tissue to resolve infection but then remain as a memory population distinct from memory T cells in lymphoid tissues. Memory T cells in adipose tissue are abundant in lean mice, and diet-induced obesity further increases memory T cell number in adipose tissue and spleen. Upon re-challenge infection, memory T cells rapidly cause severe pathogenesis, leading to increases in lipase levels, calcification of adipose tissue, pancreatitis, and reduced survival in obese mice but not lean mice. Thus, obesity leads to a unique form of viral pathogenesis involving memory T cell-dependent adipocyte destruction and damage to other tissues.

KEYWORDS:

LCMV; T cell memory; Trm; obesity; pancreatitis; tissue-resident memory T cells; white adipose tissue

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center