Send to

Choose Destination
Mov Disord. 2019 Apr 10. doi: 10.1002/mds.27699. [Epub ahead of print]

Will genotype drive treatment options?

Author information

Institute of Neurogenetics, University of Lübeck, Lübeck, Germany.
Department of Neurology, University of Lübeck, Lübeck, Germany.


Individual genetic variation can have a major impact on the clinical manifestation of a movement disorder and its response to treatment. Advances in gene discovery and increasing availability of diagnostic genetic testing have led to the identification of a growing number of patients with well-defined hereditary movement disorders. Establishing a genetic diagnosis may greatly impact patient counseling and shape therapeutic decisions. Further, assignment of a movement disorder to a specific genetic defect holds promise for the development of causal treatment approaches and individualized therapies, especially as the first gene-targeted approaches have recently entered clinical trials. However, important gaps remain, that is, genetic testing results are often inconclusive, gene-specific treatment options are still exceedingly rare, and designing clinical trials to demonstrate disease modification continues to pose a major challenge.


genetic testing; genotype; genotype-treatment relationship; hereditary movement disorders; treatment


Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center