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Eur Cell Mater. 2019 Apr 10;37:277-291. doi: 10.22203/eCM.v037a17.

Understanding tissue-engineered endochondral ossification; towards improved bone formation.

Author information

1
Department of Oral and Maxillofacial Surgery, Special Dental Care and Orthodontics, Erasmus University Medical Centre Rotterdam, Postbox 2040, 3000 CA Rotterdam, the Netherlands.e.farrell@erasmusmc.nl.

Abstract

Endochondral ossification (EO) is the process by which the long bones of the body form and has proven to be a promising method in tissue engineering for achieving cell-mediated bone formation. The present review centred on state-of-the-art research pertaining to mesenchymal stem cells (MSCs)-mediated endochondral bone formation, focusing on the role of donor cells, extracellular matrix and host immune cells during tissue-engineered bone formation. Possible research avenues to improve graft outcome and bone output were highlighted, as well as emerging research that, when applied to tissue-engineered bone grafts, offers new promise for improving the likelihood of such grafts transition from bench to bedside.

PMID:
30968944
DOI:
10.22203/eCM.v037a17
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