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Philos Trans R Soc Lond B Biol Sci. 2019 Feb 4;374(1765):20180154. doi: 10.1098/rstb.2018.0154.

Macropinocytosis and autophagy crosstalk in nutrient scavenging.

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1 Signalling Programme, Babraham Institute , Cambridge CB22 3AT , UK.
2 Cell Biology Program, Memorial Sloan Kettering Cancer Center , New York, NY 10065 , USA.


Adaptive strategies used by cells to scavenge and recycle essential nutrients are important for survival in nutrient-depleted environments such as cancer tissues. Autophagy and macropinocytosis are two major mechanisms that promote nutrient recycling and scavenging, which share considerable, yet poorly understood, cross-regulation. Here we review recent findings that connect these starvation response mechanisms and discuss the implications of their crosstalk. This article is part of the Theo Murphy meeting issue 'Macropinocytosis'.


autophagy; entosis, phagocytosis; macropinocytosis

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