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Virulence. 2019 Apr 10. [Epub ahead of print]

The roles of apoptosis, autophagy and unfolded protein response in arbovirus, influenza virus and HIV infections.

Author information

1
a Influenza and Respiratory Viruses Department , Pasteur Institute of IRAN , Tehran , Iran.
2
b Department of Internal Medicine , University of Manitoba , Winnipeg , MB , Canada.
3
d Department of Human Anatomy & Cell Science, Max Rady College of Medicine, Rady Faculty of Health Sciences , University of Manitoba , Winnipeg , MB , Canada.
4
i Children's Hospital Research Institute of Manitoba , Winnipeg , MB , Canada.
5
j Research Institute of Oncology and Hematology , CancerCare Manitoba, University of Manitoba , Winnipeg , Canada.
6
c Department of Medical Microbiology , Assiniboine Community College, School of Health and Human Services and Continuing Education , Winnipeg , MB , Canada.
7
e Department of Biology , Islamic Azad University , Mashhad Branch, Mashhad , Iran.
8
f Department of Clinical Biochemistry , Zahedan University of Medical Sciences , Zahedan , Iran.
9
g Department of Medical Microbiology and Infectious Diseases , University of Manitoba , Winnipeg , MB , Canada.
10
h Manitoba Centre for Proteomics and Systems Biology, University of Manitoba , Winnipeg , MB , Canada.
11
k Health Policy Research Centre , Shiraz Medical University of Medical Science , Shiraz , Iran.

Abstract

Virus infection induces different cellular responses in infected cells. These include cellular stress responses like autophagy and unfolded protein response (UPR). Both autophagy and UPR are connected to programmed cell death I (apoptosis) in chronic stress conditions to regulate cellular homeostasis via Bcl2 family proteins, CHOP and Beclin-1. In this review article we first briefly discuss arboviruses, influenza virus, and HIV and then describe the concepts of apoptosis, autophagy and UPR. Finally, we focus upon how apoptosis, autophagy and UPR are involved in regulation of cellular responses to arboviruses, influenza virus and HIV infections.

KEYWORDS:

Bcl2 family protein; Caspase; Cell Stress; Virus infection host response

PMID:
30966844

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