Two new secondary metabolites from the mangrove endophytic fungus Pleosporales sp. SK7

Shitong Wen; Weilong Fan; Huixian Guo; Cuiying Huang; Zhangyuan Yan; Yuhua Long

doi:10.1080/14786419.2019.1598993

Two new secondary metabolites from the mangrove endophytic fungus Pleosporales sp. SK7

Nat Prod Res. 2020 Oct;34(20):2919-2925. doi: 10.1080/14786419.2019.1598993. Epub 2019 Apr 10.

Authors

Shitong Wen¹, Weilong Fan¹, Huixian Guo¹, Cuiying Huang¹, Zhangyuan Yan¹, Yuhua Long¹

Affiliation

¹ School of Chemistry and Environment, South China Normal University, Guangzhou, China.

PMID: 30966793
DOI: 10.1080/14786419.2019.1598993

Abstract

Two new compounds, an abscisic acid-type sesquiterpene (1), and one asterric acid derivative (2), together with three known compounds (3-5) were isolated from mangrove endophytic fungus Pleosporales sp. SK7. The structures of these metabolites were determined by NMR, X-ray crystal diffraction, CD and HR-ESI-MS. All compounds were tested for their antibacterial, antioxidant and cytotoxic activities, among these compounds, 5 showed cytotoxicity against MDA-MB-435 cell with an IC₅₀ of 25.96 ± 0.32 μM.

Keywords: Mangrove fungus metabolism; Pleosporales sp.; antibacterial; antioxidant; cytotoxicity.

MeSH terms

Anti-Bacterial Agents / chemistry
Anti-Bacterial Agents / isolation & purification
Anti-Bacterial Agents / pharmacology
Antineoplastic Agents / chemistry
Antineoplastic Agents / isolation & purification
Antineoplastic Agents / pharmacology
Antioxidants / chemistry
Antioxidants / isolation & purification
Antioxidants / pharmacology
Ascomycota / chemistry
Endophytes / metabolism*
Fungi / metabolism*
Magnetic Resonance Spectroscopy
Molecular Structure
Phenyl Ethers / isolation & purification
Sesquiterpenes / isolation & purification
Wetlands*

Substances

Anti-Bacterial Agents
Antineoplastic Agents
Antioxidants
Phenyl Ethers
Sesquiterpenes
asterric acid