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Nat Prod Res. 2019 Apr 10:1-6. doi: 10.1080/14786419.2019.1599885. [Epub ahead of print]

Isolation of amylase regulators from the leaves of Ixeridium dentatum.

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a College of Pharmacy , Yonsei Institute of Pharmaceutical Science Yonsei University , Incheon , Republic of Korea.
b Institute of Marine Biochemistry , Vietnam Academy of Science and Technology , Hanoi , Vietnam.
c Department of Pharmacology and Institute of New Drug Development School of Medicine , Chonbuk National University , Chonbuk , Republic of Korea.
d Graduate School , DGIST , Daegu , Republic of Korea.


Two new compounds, one sesquiterpene lactone (1) and one phenylethanoid tautomer (2), together with eleven known compounds (3-13) were isolated from the leaves of Ixeridium dentatum. Their structures were determined by extensive spectroscopic methods, including 1D-, 2D-NMR, and mass spectrometry. All compounds were evaluated for their amylase secretion activity in human salivary gland cells after treatment in 40 mM of high glucose. All compounds showed increased amylase secretion activity. Moreover, previously undescribed compounds (1-2), luteolin 7-O-β-D-glucopyranoside (10), quercimeritrin (11), and quercetin 3-O-β-D-xylopyranoside (13) exhibited significant amylase activity, which is comparable to the positive control.


Ixeridium dentatum; amylase secretion activity; phenylethanoid; sesquiterpene lactone

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