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Polymers (Basel). 2018 Jun 8;10(6). pii: E637. doi: 10.3390/polym10060637.

Facile Preparation of Highly Stretchable and Recovery Peptide-Polyurethane/Ureas.

Gu L1,2, Jiang Y3, Hu J4.

Author information

1
Key Laboratory of Marine Materials and Related Technologies, Key Laboratory of Marine Materials and Protective Technologies of Zhejiang Province, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, Ningbo 315201, China. lin.gu@polyu.edu.hk.
2
Institute of Textiles & Clothing, The Hong Kong Polytechnic University, Hong Kong 999077, China. lin.gu@polyu.edu.hk.
3
Institute of Textiles & Clothing, The Hong Kong Polytechnic University, Hong Kong 999077, China. yuan-zhang.jiang@connect.polyu.hk.
4
Institute of Textiles & Clothing, The Hong Kong Polytechnic University, Hong Kong 999077, China. jin-lian.hu@polyu.edu.hk.

Abstract

In this work, a new class of highly stretchable peptide-polyurethane/ureas (PUUs) were synthesized containing short β-sheet forming peptide blocks of poly(γ-benzyl-l-glutamate)-b-poly(propylene glycol)-b-poly(γ-benzyl-l-glutamate) (PBLG-b-PPG-b-PBLG), isophorone diisocyanate as the hard segment, and polytetramethylene ether glycol as the soft phase. PBLG-b-PPG-b-PBLG with short peptide segment length (<10 residues) was synthesized by amine-initiated ring opening polymerization of γ-benzyl-l-glutamate-N-carboxyanhydrides (BLG-NCA), which shows mixed α-helix and β-sheet conformation, where the percent of β-sheet structure was above 48%. Morphological studies indicate that the obtained PUUs show β-sheet crystal and nanofibrous structure. Mechanical tests reveal the PUUs display medium tensile strength (0.25⁻4.6 MPa), high stretchability (>1600%), human-tissue-compatible Young's modulus (226⁻513 KPa). Furthermore, the shape recovery ratio could reach above 85% during successive cycles at high strain (500%). In this study, we report a facile synthetic method to obtain highly stretchable and recovery peptide-polyurethane/urea materials, which will have various potential applications such as wearable and implantable electronics, and biomedical devices.

KEYWORDS:

poly(γ-benzyl-l-glutamate); polyurethane/urea; shape recovery; β-sheet conformation

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