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J Cancer Res Ther. 2019;15(2):380-385. doi: 10.4103/jcrt.JCRT_384_18.

Evaluation of 24-core coaxial needle saturation biopsy of the prostate by the transperineal approach in detecting prostate cancer in patients without previous biopsy history: A single-center report.

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Department of Urology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.



The value of saturation prostate biopsy (SPBx) in patients without biopsy history remains controversial.

Materials and Methods:

A total of 644 consecutive suspected prostate cancer (PCa) cases without biopsy history were retrospectively grouped as 24-core transperineal SPBx (n = 368) guided by coaxial needle and prostate transperineal biopsy (PBx) (systematic 14-core scheme, n = 276). PCa detection rates were compared based on prostate-specific antigen (PSA) levels, PSA density (PSAD), and Gleason scores. Complications associated with those procedures were assessed.


Coaxial SPBx was superior to the 14-core scheme for overall PCa detection rates (39.67% vs. 24.64%), at PSA levels of 4.1-10.0 ng/ml (37.37% vs. 23.48%) or 10.1-20.0 ng/ml (43.31% vs. 27.21%), and PSAD <0.15 (47.80% vs. 29.23%) or 0.15-0.24 (34.07% vs. 20.93%) (all P < 0.05). In patients with positive biopsy, the rates of nonclinically significant PCa were comparable between the two biopsy groups.


Transperineal coaxial needle SPBx as the initial scheme improves PCa detection compared with initial systematic 14-core PBx, without increasing complications and overdiagnosis.


Biopsy; comparison; diagnosis; prostate cancer; transperineal approach

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