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J Cancer Res Ther. 2019;15(2):350-357. doi: 10.4103/jcrt.JCRT_243_18.

Chromatin remodeling factor lymphoid-specific helicase links with Epstein-Barr virus associated the follicular germinal center B cell lymphomas.

Author information

1
Department of Gastroenterology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
2
Department of Pathology, School of Basic Medicine, Xiangya Hospital, Central South University, Changsha, Hunan, China.
3
Center for Medicine Research, Xiangya Hospital, Central South University, Changsha, Hunan, China.
4
Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, School of Basic Medicine, Cancer Research Institute, Central South University, Changsha, Hunan, China.

Abstract

Background:

We assessed the frequency of epigenetic lesions, including lymphoid-specific helicase (LSH), 5-hydroxymethylcytosine (5-hmC) and E2F1, and the possible correlations among molecular findings, phenotype, clinical features, and outcome.

Methods:

We investigated 181 paraffin-embedded B-cell lymphoma samples using immunohistochemistry and in situ hybridization.

Results:

The levels of Ki67, LSH, 5-hmC, and E2F1 were all increased in germinal center B-cell lymphomas when compared with those in normal lymph nodes, and LSH was highly expressed in diffuse large B-cell lymphomas (DLBCLs) and Burkitt lymphomas (BLs) that were positive for Epstein-Barr virus (EBV) infection, indicating that LSH is linked to EBV infection in DLBCL and BL. Interestingly, LSH was mainly localized in the germinal centers of lymph nodes whereas 5-hmC staining localized to areas surrounding the germinal centers.

Conclusions:

These findings indicate a critical role for LSH as a biomarker and therapeutic target in follicular germinal center B-cell lymphoma.

KEYWORDS:

5-hmC; B-cell lymphomas; E2F1; germinal center; lymphoid-specific helicase

PMID:
30964110
DOI:
10.4103/jcrt.JCRT_243_18
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