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Curr Med Chem. 2019 Apr 9. doi: 10.2174/0929867326666190409130207. [Epub ahead of print]

Recent advance in polymer based microspheric systems for controlled protein and peptide delivery.

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Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515. China.
International Institute for Translational Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong 510006. China.
Department of Chemical and Biomedical Engineering, West Virginia University, Morgantown, WV, 26505. United States.


Sustained-release systems made by biodegradable polymers for protein and peptide drug delivery have received considerable attention by academic researchers and major pharmaceutical companies around the world. Various types of biodegradable materials, including natural and synthetic polymers, have been applied to form protein and peptide drug carriers. Among these material candidates, poly lactic acid (PLA) and poly lactic-co-glycolic acid (PLGA) are the most commonly used biodegradable materials in the development of protein and peptide microspheres. In addition, many microsphere preparation technologies, including spray drying, coacervation, multiple emulsion solvent evaporation method and microporous membrane emulsification have been developed for microspheres preparation. In this review, we particularly summarize and briefly introduce the materials and methods that are used to fabricate microspheres as protein delivery systems. The existing opportunities and challenges for successful protein delivery are also discussed.


Drug delivery; Microporous membrane emulsification technology ; Microspheres; Protein and peptide drugs; Sustained-release system

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