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Tissue Eng Part A. 2019 May;25(9-10):799-808. doi: 10.1089/ten.TEA.2019.0007.

Subretinal Transplant of Induced Pluripotent Stem Cell-Derived Retinal Pigment Epithelium on Nanostructured Fibrin-Agarose.

Author information

1
1 Regeneration and Cell Therapy Department, Andalusian Center for Molecular Biology and Regenerative Medicine (CABIMER), Seville, Spain.
2
2 Unidad de Producción y Reprogramación Celular, Iniciativa Andaluza en Terapias Avanzadas, Sevilla, Spain.
3
3 University Hospital Virgen Macarena, Sevilla, Spain.
4
4 RETICS Oftared, Carlos III Institute of Health (Spain), Ministry of Health RD16/0008/0010, Sevilla, Spain.

Abstract

In the promising field of cellular therapy for retinal degenerative diseases, a new biomaterial is proposed as a scaffold to grow and surgically introduce a monolayer of retinal pigment epithelial cells into the subretinal space, keeping the orientation of the cells for a proper functional integration of the transplant. The use of induced pluripotent stem cells as the starting material for retinal pigment epithelial cells is intended to advance toward a personalized medicine approach.

KEYWORDS:

fibrin-agarose hydrogel; induced pluripotent stem cells; macular degeneration; retinal pigment epithelium; subretinal implant

PMID:
30963803
DOI:
10.1089/ten.TEA.2019.0007

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