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J Thorac Dis. 2019 Feb;11(2):410-417. doi: 10.21037/jtd.2019.01.51.

Clinical efficacy of high-flow oxygen therapy through nasal cannula in patients with acute heart failure.

Author information

1
Division of Cardiologye, Department of Internal Medicine, College of Medicine, Gyeongsang National University, Gyeongsang National University Hospital, Jinju, Korea.
2
Division of Pulmonology and Critical Care, Department of Internal Medicine, College of Medicine, Gyeongsang National University, Gyeongsang National University Hospital, Jinju, Korea.
3
Department of Internal Medicine, Gyeongsang National University School of Medicine and Cardiovascular Center, Gyeongsang National University Changwon Hospital, Changwon, Korea.

Abstract

Background:

High-flow oxygen therapy through nasal cannula (HFNC) could reduce intubation rate and mortality rate among patients with acute respiratory failure. We evaluated the physiological responses and clinical outcomes of HFNC in patients with acute heart failure (AHF).

Methods:

A retrospective cohort analysis was performed in single medical tertiary center. Patients with AHF who had a progressive hypoxemia after oxygenation via facemask were divided into intubation group and HFNC group. We analyzed the physiological responses and in-hospital clinical outcomes between two groups.

Results:

Seventy-three patients of intubation group and 76 patients of HFNC group were included. Baseline characteristics were well-balanced between two groups. There were no differences in changes of mean arterial pressure, heart rate, and pulse oxygen saturation during the first 6 hours. Among HFNC group, 66 of 76 patients (86.8%) were successfully recovered from progressive hypoxemia without endotracheal intubation, and there were no differences in in-hospital clinical outcomes between two groups.

Conclusions:

This study showed HFNC group had a similar result of improvement of oxygen saturation and in-hospital clinical outcomes compared with intubation group in AHF. Present study supported HFNC could be considered as initial choice of oxygen therapy in selected patients of AHF.

KEYWORDS:

Acute heart failure (AHF); high-flow oxygen therapy through nasal cannula (HFNC); in-hospital clinical outcomes; intubation; physiological responses

Conflict of interest statement

Conflicts of Interest: The authors have no conflicts of interest to declare.

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