Cancer Cells Thrive on Stress

Lorenzo Galluzzi; Guido Kroemer

doi:10.1016/j.tcb.2019.03.005

Cancer Cells Thrive on Stress

Trends Cell Biol. 2019 Jun;29(6):447-449. doi: 10.1016/j.tcb.2019.03.005. Epub 2019 Apr 5.

Authors

Lorenzo Galluzzi¹, Guido Kroemer²

Affiliations

¹ Department of Radiation Oncology, Weill Cornell Medical College, New York, NY, USA; Sandra and Edward Meyer Cancer Center, New York, NY, USA; Department of Dermatology, Yale School of Medicine, New Haven, CT, USA; Université Paris Descartes, Paris, France. Electronic address: deadoc80@gmail.com.
² Equipe Labellisée par la Ligue Contre le Cancer, Université Paris Descartes, Université Paris Diderot, Université Sorbonne Paris Cité, INSERM U1138, Centre de Recherche des Cordeliers, Paris, France; Metabolomics and Cell Biology Platforms, Institut Gustave Roussy, Villejuif, France; Pôle de Biologie, Hôpital Européen Georges Pompidou, AP-HP, Paris, France; Suzhou Institute for Systems Biology, Chinese Academy of Sciences, Suzhou, China; Department of Women's and Children's Health, Karolinska University Hospital, Stockholm, Sweden.

PMID: 30962044
DOI: 10.1016/j.tcb.2019.03.005

Abstract

Glucocorticoids (GCs) are widely used for the management of disease- or therapy-related complications in cancer patients. Recent data indicate that activation of GC receptors (GRs) precipitates breast cancer progression by favoring metastatic dissemination and cell survival at distant sites. These findings call for the re-evaluation of GC usage in patients with cancer.

Keywords: ROR1; circulating tumor cells; dormancy; immunotherapy; social stress; triple negative breast cancer.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Review

MeSH terms

Glucocorticoids / metabolism
Humans
Neoplasms / metabolism*
Neoplasms / pathology
Oxidative Stress*
Receptors, Glucocorticoid / metabolism

Substances

Glucocorticoids
Receptors, Glucocorticoid