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Prog Brain Res. 2019;245:145-200. doi: 10.1016/bs.pbr.2019.03.009. Epub 2019 Apr 2.

Nanowired delivery of cerebrolysin with neprilysin and p-Tau antibodies induces superior neuroprotection in Alzheimer's disease.

Author information

1
International Experimental Central Nervous System Injury & Repair (IECNSIR), Department of Surgical Sciences, Anesthesiology & Intensive Care Medicine, Uppsala University Hospital, Uppsala University, Uppsala, Sweden. Electronic address: sharma@surgsci.uu.se.
2
Department of Clinical Neurosciences, University of Medicine & Pharmacy, Cluj-Napoca, Romania; "RoNeuro" Institute for Neurological Research and Diagnostic, Cluj-Napoca, Romania.
3
Department of Pathology, University of Maryland, Baltimore, MD, United States.
4
Anesthesiology & Intensive Care, Massachusetts General Hospital, Boston, MA, United States.
5
LaNCE, Department of Neuroscience, University of the Basque Country (UPV/EHU), Leioa, Spain.
6
Department of Chemistry & Biochemistry, University of Arkansas, Fayetteville, AR, United States.
7
Department of Biomedical Engineering, University of Arkansas, Fayetteville, AR, United States.
8
National Scientific Centre of Marine Biology, Far Eastern Branch, Russian Academy of Sciences, Vladivostok, Russia; School of Biomedicine, Far Eastern Federal University, Vladivostok, Russia.
9
Ever NeuroPharma, Oberburgau, Austria.
10
International Experimental Central Nervous System Injury & Repair (IECNSIR), Department of Surgical Sciences, Anesthesiology & Intensive Care Medicine, Uppsala University Hospital, Uppsala University, Uppsala, Sweden.

Abstract

Alzheimer's disease (AD) is estimated to be afflicting over 55 millions of individual worldwide in 2018-19 for which no suitable clinical therapeutic measures have been developed so far. Thus, there is an urgent need to explore novel therapeutic strategies using nanodelivery of drugs and agents either alone or in combination for superior neuroprotection in AD and enhanced quality of life of the affected individuals. There are reports that AD is often associated with diminished neurotrophic factors and neprilysin together with enhancement of phosphorylated Tau (p-Tau) within the brain and in the cerebrospinal fluid (CSF). Thus, studies aiming to enhance neurotrophic factors and neprilysin together with neutralizing p-Tau within the central nervous system (CNS) may alleviate brain pathology in AD. In this review these strategies are discussed using nanotechnological approaches largely based on our own investigations in relation to current literature in the field.

KEYWORDS:

Alzheimer's disease; Antibodies; Blood-brain barrier; Brain edema; Brain pathology; Cerebrolysin; Nanowired delivery; Neurotrophic factors; Phosphorylated Tau protein

PMID:
30961867
DOI:
10.1016/bs.pbr.2019.03.009
[Indexed for MEDLINE]

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