Send to

Choose Destination
J Headache Pain. 2019 Apr 8;20(1):35. doi: 10.1186/s10194-019-0985-0.

Primary headaches during lifespan.

Author information

Department of Neurology, University Hospital LMU, Ludwig-Maximilians-University, 81377, Munich, Germany.
Headache Research, Wolfson CARD, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.
The Headache Centre, Guy's and St Thomas' NHS Foundation Trust, London, UK.


Primary headaches are one of the most prevalent neurological disorders and can occur during a wide range of lifespan. Primary headaches, especially migraine, are cyclic disorders with a complex sequence of symptoms within every headache attack. There is no systematic review of whether these symptoms changes during lifespan. Indeed, the clinical presentation of migraine shows an age-dependent change with a significantly shorter duration of the attacks and occurrence of different paroxysmal symptoms, such as vomiting, abdominal pain or vertigo, in childhood and, in contrast, largely an absence of autonomic signs and a more often bilateral headache in the elderly. The age-dependent differences in the clinical presentation are less distinct in cluster headache and, especially, in tension-type headache. The differences in the clinical presentation are in agreement with the idea that the connectivity of hypothalamic areas with different brainstem areas, especially the central parasympathetic areas, is important for the clinical manifestation of migraine, as well as, the change during lifespan.


Adults; Aura; Children; Clinical symptoms; Cluster headache; Elderly; Hypothalamus; Migraine; Migraine-related syndromes; Parasympathetic; Sympathetic; Tension-type headache

Free full text

Supplemental Content

Full text links

Icon for BioMed Central
Loading ...
Support Center