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Polymers (Basel). 2018 Jul 16;10(7). pii: E780. doi: 10.3390/polym10070780.

Preparation of Molecularly Imprinted Microspheres as Biomimetic Recognition Material for In Situ Adsorption and Selective Chemiluminescence Determination of Bisphenol A.

Author information

1
School of Chemistry and Chemical Engineering, Southwest Petroleum University, Chengdu 610500, China. xiongyan207@163.com.
2
Oil and Gas Field Applied Chemistry Key Laboratory of Sichuan Province, Southwest Petroleum University, Chengdu 610500, China. xiongyan207@163.com.
3
School of Chemistry and Chemical Engineering, Southwest Petroleum University, Chengdu 610500, China. qwang@163.com.
4
School of Chemistry and Chemical Engineering, Southwest Petroleum University, Chengdu 610500, China. mduan124@swpu.edu.cn.
5
Oil and Gas Field Applied Chemistry Key Laboratory of Sichuan Province, Southwest Petroleum University, Chengdu 610500, China. mduan124@swpu.edu.cn.
6
Liaoning Entry-Exit Inspection and Quarantine Bureau, Dalian 116001, China. jingxu99@163.com.
7
School of Chemistry and Chemical Engineering, Southwest Petroleum University, Chengdu 610500, China. jiechen92@163.com.
8
School of Chemistry and Chemical Engineering, Southwest Petroleum University, Chengdu 610500, China. swhen@163.com.
9
Oil and Gas Field Applied Chemistry Key Laboratory of Sichuan Province, Southwest Petroleum University, Chengdu 610500, China. swhen@163.com.

Abstract

Bisphenol A (BPA) is an endocrine disrupter in environments which can induce abnormal differentiation of reproductive organs by interfering with the action of endogenous gonadal steroid hormones. In this work, the bisphenol A (BPA) molecularly-imprinted microspheres (MIMS) were prepared and used as biomimetic recognition material for in situ adsorption and selective chemiluminescence (CL) determination of BPA. Through non-covalent interaction, the BPA-MIMS was successfully prepared by Pickering emulsion polymerization using a BPA template, 4-vinylpyridine (4-VP) monomer, ethylene glycol dimethacrylate (EGDMA) cross-linker, and a SiO₂ dispersion agent. The characterization of scanning electron microscopy (SEM) and energy-disperse spectroscopy (EDS) showed that the obtained MIMS possessed a regular spherical shape and narrow diameter distribution (25⁻30 μm). The binding experiment indicated BPA could be adsorbed in situ on the MIMS-packing cell with an apparent maximum amount Qmax of 677.3 μg g-1. Then BPA could be selectively detected by its sensitive inhibition effect on the CL reaction between luminol and periodate (KIO₄), and the inhibition mechanism was discussed to reveal the CL reaction process. The CL intensity was linear to BPA concentrations in two ranges, respectively from 0.5 to 1.5 μg mL-1 with a detection limit of 8.0 ng mL-1 (3σ), and from 1.5 to 15 μg mL-1 with a limit of detection (LOD) of 80 ng mL-1 (3σ). The BPA-MIPMS showed excellent selectivity for BPA adsorption and the proposed CL method has been successfully applied to BPA determination in environmental water samples.

KEYWORDS:

bisphenol A; chemiluminescence determination; in situ adsorption; molecularly imprinted microsphere (MIMS); selectivity

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