Format

Send to

Choose Destination
Molecules. 2019 Apr 7;24(7). pii: E1364. doi: 10.3390/molecules24071364.

Piper Species: A Comprehensive Review on Their Phytochemistry, Biological Activities and Applications.

Author information

1
Student Research Committee, School of Medicine, Bam University of Medical Sciences, Bam 44340847, Iran. bahar.salehi007@gmail.com.
2
Department of Biomedical Science, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia. dr_zaz@yahoo.com.
3
Department of Food and Nutritional Sciences, North Carolina A&T State University, Greensboro, NC 27411, USA. rgyawali@gmail.com.
4
Department of Food and Nutritional Sciences, North Carolina A&T State University, Greensboro, NC 27411, USA. ibrah001@ncat.edu.
5
Institute of Pharmacology, Clinical Pharmacology and Toxicology, Medical Faculty, University of Belgrade, 11129 Belgrade, Serbia. jolarajkovic@yahoo.com.
6
Department of Biotechnology, Quaid-i-Azam University, Islamabad, 45320, Pakistan. shinwari2008@gmail.com.
7
Department of Biotechnology, Quaid-i-Azam University, Islamabad, 45320, Pakistan. tariqkhanbio@gmail.com.
8
Food Safety Research Center (salt), Semnan University of Medical Sciences, Semnan 35198-99951, Iran. javad.sharifirad@gmail.com.
9
Graduate Program of Biomolecular Sciences, Institute of Natural and Applied Sciences, Canakkale Onsekiz Mart University, 17020 Canakkale, Turkey. ademozleyen@gmail.com.
10
Graduate Program of Biomolecular Sciences, Institute of Natural and Applied Sciences, Canakkale Onsekiz Mart University, 17020 Canakkale, Turkey. elifturkdonmez@stu.comu.edu.tr.
11
European Herbal and Traditional Medicine Practitioners Association (EHTPA), 25 Lincoln Close, GL20 5TY Tewkesbury, UK. marco.officinalessinia@gmail.com.
12
Department of Molecular Biology and Genetics, Faculty of Arts and Science, Canakkale Onsekiz Mart University, 17020 Canakkale, Turkey. tumertb@gmail.com.
13
Parasitology Department, Institute of Tropical Medicine "Pedro Kouri", 10400 Havana, Cuba. monzote@ipk.sld.cu.
14
Department of Nutrition and Dietetics, Faculty of Pharmacy, University of Concepcion, 4070386 Concepcion, VIII-Bio Bio Region, Chile. mmartorell@udec.cl.
15
Department of Chemistry, University of Alabama in Huntsville, Huntsville, AL 35899, USA. wsetzer@chemistry.uah.edu.
16
Aromatic Plant Research Center, 230 N 1200 E, Suite 100, Lehi, UT 84043, USA. wsetzer@chemistry.uah.edu.

Abstract

Piper species are aromatic plants used as spices in the kitchen, but their secondary metabolites have also shown biological effects on human health. These plants are rich in essential oils, which can be found in their fruits, seeds, leaves, branches, roots and stems. Some Piper species have simple chemical profiles, while others, such as Piper nigrum, Piper betle, and Piper auritum, contain very diverse suites of secondary metabolites. In traditional medicine, Piper species have been used worldwide to treat several diseases such as urological problems, skin, liver and stomach ailments, for wound healing, and as antipyretic and anti-inflammatory agents. In addition, Piper species could be used as natural antioxidants and antimicrobial agents in food preservation. The phytochemicals and essential oils of Piper species have shown strong antioxidant activity, in comparison with synthetic antioxidants, and demonstrated antibacterial and antifungal activities against human pathogens. Moreover, Piper species possess therapeutic and preventive potential against several chronic disorders. Among the functional properties of Piper plants/extracts/active components the antiproliferative, anti-inflammatory, and neuropharmacological activities of the extracts and extract-derived bioactive constituents are thought to be key effects for the protection against chronic conditions, based on preclinical in vitro and in vivo studies, besides clinical studies. Habitats and cultivation of Piper species are also covered in this review. In this current work, available literature of chemical constituents of the essential oils Piper plants, their use in traditional medicine, their applications as a food preservative, their antiparasitic activities and other important biological activities are reviewed.

KEYWORDS:

anti-inflammatory; anticancer; antimicrobial; essential oil; pepper; traditional medicine

PMID:
30959974
PMCID:
PMC6479398
DOI:
10.3390/molecules24071364
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Multidisciplinary Digital Publishing Institute (MDPI) Icon for PubMed Central
Loading ...
Support Center