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Toxicology. 2019 May 15;420:66-72. doi: 10.1016/j.tox.2019.03.016. Epub 2019 Apr 5.

Bisphenol F has different effects on preadipocytes differentiation and weight gain in adult mice as compared with Bisphenol A and S.

Author information

1
Center for Human Health and the Environment and Department of Biological Sciences, North Carolina State University, Raleigh, NC, 27695, United States.
2
Center for Human Health and the Environment and Department of Biological Sciences, North Carolina State University, Raleigh, NC, 27695, United States; Discovery Sciences, RTI International, Research Triangle Park, NC, 27709, United States.
3
Center for Human Health and the Environment and Department of Biological Sciences, North Carolina State University, Raleigh, NC, 27695, United States. Electronic address: efrissma@ncsu.edu.

Abstract

Bisphenol S (2,2-bisulfone, BPS) and Bisphenol F (2,2-bis [4-hydroxyphenol]methane, BPF) are analogs of Bisphenol A (2,2-bis[4-hydroxyphenyl]propane, BPA), a widely used endocrine disrupting compound present in polycarbonate plastics, thermal receipts and epoxy resins that line food cans. Here we examined effects of BPA, BPS, and BPF in low concentrations on differentiation in murine 3T3-L1 preadipocytes. We also fed adult male mice chow with one of three doses of BPF (0, 0.5, 5, 50 mg/kg chow, or approximately 0.044, 0.44 and 4.4 mg/kg body weight per day) for 12 weeks, collected body weights, food intake, and tested for glucose tolerance. The doses of BPF used produced mean concentrations of 0, 6.2, 43.6, and 561 ng/mL in plasma. In 3T3-L1 cells BPS had the greatest effects, along with BPA, both increased expression of several genes required for preadipocyte differentiation over 12 days in culture. In contrast, BPF decreased expression of several genes late in differentiation. This dichotomy was also reflected in lipid accumulation as BPA and BPS treated cells had elevated lipid concentrations compared to controls or cells treated with BPF. Male mice fed either the highest or lowest concentrations of BPF gained less weight than controls with no effects on glucose levels or glucose tolerance. Plasma levels of BPF reflected doses in food with no overlap between doses. In summary, our results suggest that BPS has a strong potential to be obesogenic while effects of BPF are subtler and potentially in the opposite direction.

KEYWORDS:

Alternatives to BPA; BPF; Bisphenol; Diabetes; Fat; Metabolism

PMID:
30959087
PMCID:
PMC6574128
[Available on 2020-05-15]
DOI:
10.1016/j.tox.2019.03.016

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