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BJU Int. 2019 Apr 8. doi: 10.1111/bju.14765. [Epub ahead of print]

The Status and Characteristics of Urinary Stone Composition in China.

Ye Z1,2, Zeng G3, Huan Y1,2, Li J4, Tang K1,2, Wang G5, Wang S6, Yu Y7, Wang Y8, Zhang T9, Long Y10, Li W11, Wang C12, Wang W13, Gao S14, Shan Y15, Huang X16, Bai Z17, Lin X18, Cheng Y19, Wang Q20, Xu Z21, Xie L22, Yuan J23, Ren S24, Fan Y25, Pan T26, Wang J27, Li X28, Chen X29, Gu X29, Sun Z30, Xiao K31, Jia J32, Zhang Q33, Wang G34, Sun T34, Li X35, Xu C36, Xu C37, Shi G38, He J38, Song L39, Sun G40, Wang D41, Liu Y42, Wang C43, Han Y44, Liang P45, Wang Z46, He W1,2, Chen Z1,2, Xing J47, Xu H1,2.

Author information

1
Department of Urology, Tongji Hospital, Tongji Medical School, Huazhong University of Science and Technology, Wuhan, China.
2
Hubei Institute of Urology, Wuhan, China.
3
Department of Urology, Minimally Invasive Surgery Center, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
4
Department of Urology, Beijing Tsinghua changgung Hospital, Beijing, China.
5
Department of Urology, Zhongshan Hospital, Shanghai Medical College of Fudan University, Shanghai, China.
6
Department of Urology, GuangDong Province Hospital Of Traditional Chinese Medicine, Guangzhou, China.
7
Department of Urology, The No. 181 Hospital of the People's Liberation Army, Guilin, China.
8
Department of Urology, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, China.
9
Department of Urology, The No. 5 Hospital of The People's Liberation Army, Yinchuan, China.
10
Department of Urology, Shaoyang Central Hospital, Shaoyang, China.
11
Department of Urology, The Third Affiliated Hospital of Chongqing Medical University, Chongqing, China.
12
Department of laboratory, The People's Hospital of Xinjiang Autonomous Region, Urumqi, China.
13
Department of Urology, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
14
Department of Urology, Gaomi City Hospital of Traditional Chinese Medicine, Gaomi, China.
15
Department of Urology, The Second Hospital of Suzhou University Medical School, Suzhou, China.
16
Department of Urology, Peking University People's Hospital, Beijing, China.
17
Department of Urology, Haikou People's Hospital, Haikou, China.
18
Department of Urology, The Second Hospital of Xiamen City, Xiamen, China.
19
Department of Urology, The First People's Hospital of Ningbo City, Ningbo University Medical School, Ningbo, China.
20
Department of Urology, The First Affiliated Hospital of Shihezi University Medical School, Shihezi, China.
21
Department of Urology, Wuxi People's Hospital of Nanjing Medical University, Wuxi, China.
22
Department of Urology, The First Affiliated Hospital of Medical School of Zhejiang University, Hangzhou, China.
23
Department of Urology, Xijing Hospital of the Fourth Military Medical University, Xi'an, China.
24
Department of Urology, The No. 113 Hospital of the People's Liberation Army, Ningbo, China.
25
Department of Urology, Xi'an Gaoxin Hospital, Xi'an, China.
26
Department of Urology, Wuhan General Hospital of Guangzhou Military Region, Wuhan, China.
27
Department of Urology, The First People's Hospital of Changshu City, Changshu, China.
28
Department of Urology, the Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
29
Department of Urology, Jiangsu Province Hospital Of Traditional Chinese Medicine, Nanjing, China.
30
Department of Urology, The People's Hospital of Guizhou Province, Guiyang, China.
31
Department of Urology, The People's Hospital of Shenzhen City, Shenzhen, China.
32
Department of Urology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
33
Department of Urology, Taizhou Municipal Hospital, Taizhou, China.
34
Department of Urology, The First Affiliated Hospital of Nanchang University, Nanchang, China.
35
Department of Urology, The Second Affiliated Hospital of Harbin Medical University, Harbin, China.
36
Department of Urology, The Second Affiliated Hospital of Zhengzhou University Medical School, Zhengzhou, China.
37
Department of Urology, Changhai Hospital, Second Military Medical University, Shanghai, China.
38
Department of Urology, The Fifth People's Hospital of Shanghai City, Shanghai, China.
39
Department of Urology, Ganzhou People's Hospital, Ganzhou, China.
40
Department of Urology, The Second Affiliated Hospital of Tianjin Medical University, Tianjin, China.
41
Department of Urology, The First Affiliated Hospital of Shanxi Medical University, Taiyuan, China.
42
Department of Urology, The Fourth Affiliated Hospital of China Medical University, Shenyang, China.
43
Department of Urology, The First Hospital of Jilin University, Changchun, China.
44
Department of Urology, Shenyang Red-Cross Hospital, Shenyang, China.
45
Department of Urology, The Affiliated Hospital of Hainan Medical College, Haikou, China.
46
Department of Urology, The Second Hospital of Lanzhou University Medical School, Lanzhou, China.
47
Department of Urology, The First Affiliated Hospital of Xiamen University, Xiamen, China.

Abstract

OBJECTIVES:

To explore characteristics of urinary stone composition in China, and determine the effects of gender, age, body mass index (BMI), stone location and geographic region on stone composition.

SUBJECTS AND METHODS:

We prospectively used Fourier transform infrared spectroscopy to analyse stones from consecutive patients presenting with new-onset urolithiasis at 46 hospitals in seven geographic areas of China between June 1, 2010 and May 31, 2015.Chi-squared tests and logistic regression analyses were performed to determine associations between stone composition and gender, age, BMI, stone location, and geographic region.

RESULTS:

The most common stone components were calcium oxalate (CaOx; 65.9%), carbapatite (15.6%), urate (12.4%), struvite (2.7%), brushite (1.7%). CaOx and urate stones occurred more frequently in males, whereas carbapatite and struvite were more common in females (p<0.01). CaOx and carbapatite were more common in those 30-50 and 20-40 years old respectively than in other groups. Brushite and struvite were most common among those younger than 20 and older than 70 years old. The detection rate of urate increased with age,however cystine decreased with age. Obese patients were more likely to have urate stones than carbapatite or brushite stones (p<0.01). CaOx, carbapatite, brushite, and cystine stones were more frequently observed in the kidney than other types, whereas urate and struvite were more frequent in the bladder (p<0.01). Stone composition varied by geographic region.

CONCLUSIONS:

The most common stone compositions were CaOx, carbapatite, urate, struvite, brushite in turn. Stone composition differed significantly in patients grouped by gender, age, BMI, stone location, and geographic region. This article is protected by copyright. All rights reserved.

PMID:
30958622
DOI:
10.1111/bju.14765

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