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J Leukoc Biol. 2019 Apr 8. doi: 10.1002/JLB.6RU0918-353RRRR. [Epub ahead of print]

The expanding family of noncanonical regulatory cell subsets.

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Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu, China.


The overwhelming body of research on regulatory lymphocytes has focused on CD4+ CD25+ Foxp3+ T cells (regulatory T cells); however, the last 5 years have witnessed inspiring progress in our understanding of regulatory B cells, regulatory CD8+ T cells, regulatory γδ cells, and, more recently, regulatory innate lymphoid cells(ILCregs). This review focuses on these so-called noncanonical regulatory cell subsets. We primarily survey existing information on the phenotype, function, sustaining factors, and clinical value of the 4 best-characterized non-CD4 + Foxp3+ T regulatory cells. We then take a brief journey into the advances and challenges associated with next-generation sequencing technologies and the application of sequencing to the study of noncanonical regulatory cell subsets.


Bregs; CD8+ Tregs; ILCregs; regulatory cells; γδ-Tregs

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