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Angew Chem Int Ed Engl. 2019 Jun 3;58(23):7808-7812. doi: 10.1002/anie.201903475. Epub 2019 May 6.

Metal-Organic Framework (MOF) Hybrid as a Tandem Catalyst for Enhanced Therapy against Hypoxic Tumor Cells.

Author information

1
State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, 210023, China.

Abstract

Encapsulation of active biomolecules and/or nanoparticles in metal-organic frameworks (MOFs) remains a great challenge in biomedical applications. In this work, through a stepwise in situ growth method, a black phosphorus quantum dot (BQ) and catalase were precisely encapsulated into the inner and outer layers of MOFs, respectively. The integrated MOF system as a tandem catalyst could convert H2 O2 into O2 in MOF-stabilized catalase outer layer, and then O2 was directly injected into MOF-sensitized BQ inner, leading to high quantum yield of singlet oxygen. Upon internalization, the photodynamic therapy efficiency of the MOF system was 8.7-fold greater than that without catalase, showing an enhanced therapeutic effect against hypoxic tumor cells. Furthermore, by coupling with photothermal therapy of BQs, photodynamic-thermal synergistic therapy was realized both in vitro and in vivo.

KEYWORDS:

black phosphorus; encapsulation; fluorescent probes; metal-organic frameworks (MOFs); photodynamic therapy

PMID:
30957318
DOI:
10.1002/anie.201903475

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