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Headache. 2019 Apr;59(4):632-634. doi: 10.1111/head.13520. Epub 2019 Apr 7.

Did Going North Give Us Migraine? An Evolutionary Approach on Understanding Latitudinal Differences in Migraine Epidemiology.

Author information

1
NeuroCritical Care Unit & Headache Centre, Department of Human Neurosciences, Sapienza - University of Rome, Rome, Italy.
2
Brain Morphometry and Dynamics, Department of Anatomy, Histology, Forensic Medicine and Orthopaedics, Sapienza - University of Rome, Rome, Italy.
3
Department of Zoology, University of Cambridge, Cambridge, United Kingdom.
4
University Consortium for Adaptive Disorders and Head Pain - UCADH, Pavia, Italy.

Abstract

This commentary discusses a recent publication by evolutionary biologists with strong implications for migraine experts. The Authors showed that a gene polymorphism associated with migraine gave our ancestors an evolutionary advantage when colonizing northern, and thus colder, territories. They then highlight that the prevalence of migraine may differ among countries because of climatic adaptation. These results may prove useful in planning both epidemiological and physiological studies in the field of migraine.

KEYWORDS:

TRPM8; cold adaptation; evolutionary biology; latitude; migraine; migraine epidemiology

PMID:
30957222
DOI:
10.1111/head.13520

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