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Clin Exp Gastroenterol Hepatol. 2019 Jan-May;1(1). pii: 105. Epub 2019 Mar 8.

Baseline Hepatic Levels of miR-29b and Claudin are Respectively Associated with the Stage of Fibrosis and HCV RNA in Hepatitis C.

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The Liver-Biliary-Pancreatic Center, Carolinas Medical Center, Charlotte, NC, USA.
Department of Biology, University of North Carolina at Charlotte, Charlotte, NC, USA.
Center for Nanotechnology in Drug Delivery, UNC School of Pharmacy, Chapel Hill, NC, USA.
Department of pathology, Carolinas Medical Center, Charlotte, NC, USA.
Division of Gastroenterology, Department of Internal Medicine, Wake Forest University Medical Center, Winston-Salem, NC, USA.


We sought to determine if the baseline hepatic levels of miR-122, miR-29b, Claudin, Occludin, Protein Kinase R (PKR) or PKR activator (PRKRA) were correlated with HCV RNA or stage of fibrosis in patients with chronic hepatitis C (CHC). A total of 25 CHC patients (genotype 1) who were treatment naive at the time of sample collection enrolled in this study. By multivariate analysis, CLDN RNA was found as the single independent factor positively correlated with HCV RNA levels (p=0.003), while hepatic miR-29b levels was found as the single independent factor for predicting advanced stage of fibrosis (p=0.028). Conclusion: Our results highlight miR-29b and CLDN as novel predictors of advanced stage of liver fibrosis and baseline HCV RNA in CHC.


HCV; HCV RNA; Occludin; miR-122; miRNA; micro RNA


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