Send to

Choose Destination
J Epidemiol. 2019 Apr 6. doi: 10.2188/jea.JE20180220. [Epub ahead of print]

Study Design and Baseline Profiles of Participants in the Uonuma CKD Cohort Study in Niigata, Japan.

Author information

Department of Health Promotion Medicine, Niigata University Graduate School of Medical and Dental Sciences.
Division of Preventive Medicine, Niigata University Graduate School of Medical and Dental Sciences.
Department of Food Science and Nutrition, Nara Women's University Graduate School of Humanities and Sciences.
Epidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center.
Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences.



Evidence for primary prevention of chronic kidney disease (CKD) is insufficient. The population-based prospective Uonuma CKD cohort study aims to explore associations of lifestyle and other risk factors with CKD. We report here the study design and baseline profiles.


All 67,322 residents aged ≥40 years in Minamiuonuma City, Uonuma City, and Yuzawa Town, Niigata Prefecture, Japan and 11,406 who attended local health-check examinations were targeted for baseline questionnaire and biochemical sampling, respectively. Information was gathered from 43,217 (64.2%) questionnaires and 8,052 (70.6%) biochemical samples; 6,945 participants consented to both questionnaire and biochemical sampling at baseline, conducted between fiscal 2012 and 2015. Participants provided information regarding sociodemographic, lifestyle, and self-reported outcomes. Urine albumin-to-creatinine ratio (ACR) and estimated glomerular filtration rate (eGFR) were measured. The primary outcome is CKD based on self-report and biochemical/clinical diagnosis.


Mean (standard deviation) age of questionnaire respondents was 63.3 (12.5) years for men and 64.3 (13.3) years for women. Among participants who submitted urine samples, median ACR (interquartile range; IQR) was 10.0 (5.0-24.0) mg/g for men and 13.0 (7.7-27.0) mg/g for women, and median eGFR (IQR) was 73.6 mL/min/1.73 m2 (63.5-84.5) for men and 73.5 mL/min/1.73m2 (64.4-83.5) for women. ACR 30 mg/g or more was found in 1,741 participants (21.7%) and eGFR <60 mL/min/1.73 m2 in 1,361 participants (16.9%).


The Uonuma CKD cohort study was established to investigate the impact of lifestyle on CKD development and to provide data for preventing the onset and progression of CKD.


Chronic Kidney Disease; Cohort Studies; Lifestyle; Risk Factors

[Available on 2020-04-05]
Free full text

Supplemental Content

Full text links

Icon for J-STAGE, Japan Science and Technology Information Aggregator, Electronic
Loading ...
Support Center