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J Epidemiol. 2019 Apr 6. doi: 10.2188/jea.JE20180220. [Epub ahead of print]

Study Design and Baseline Profiles of Participants in the Uonuma CKD Cohort Study in Niigata, Japan.

Author information

1
Department of Health Promotion Medicine, Niigata University Graduate School of Medical and Dental Sciences.
2
Division of Preventive Medicine, Niigata University Graduate School of Medical and Dental Sciences.
3
Department of Food Science and Nutrition, Nara Women's University Graduate School of Humanities and Sciences.
4
Epidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center.
5
Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences.

Abstract

BACKGROUND:

Evidence for primary prevention of chronic kidney disease (CKD) is insufficient. The population-based prospective Uonuma CKD cohort study aims to explore associations of lifestyle and other risk factors with CKD. We report here the study design and baseline profiles.

METHODS:

All 67,322 residents aged ≥40 years in Minamiuonuma City, Uonuma City, and Yuzawa Town, Niigata Prefecture, Japan and 11,406 who attended local health-check examinations were targeted for baseline questionnaire and biochemical sampling, respectively. Information was gathered from 43,217 (64.2%) questionnaires and 8,052 (70.6%) biochemical samples; 6,945 participants consented to both questionnaire and biochemical sampling at baseline, conducted between fiscal 2012 and 2015. Participants provided information regarding sociodemographic, lifestyle, and self-reported outcomes. Urine albumin-to-creatinine ratio (ACR) and estimated glomerular filtration rate (eGFR) were measured. The primary outcome is CKD based on self-report and biochemical/clinical diagnosis.

RESULTS:

Mean (standard deviation) age of questionnaire respondents was 63.3 (12.5) years for men and 64.3 (13.3) years for women. Among participants who submitted urine samples, median ACR (interquartile range; IQR) was 10.0 (5.0-24.0) mg/g for men and 13.0 (7.7-27.0) mg/g for women, and median eGFR (IQR) was 73.6 mL/min/1.73 m2 (63.5-84.5) for men and 73.5 mL/min/1.73m2 (64.4-83.5) for women. ACR 30 mg/g or more was found in 1,741 participants (21.7%) and eGFR <60 mL/min/1.73 m2 in 1,361 participants (16.9%).

CONCLUSION:

The Uonuma CKD cohort study was established to investigate the impact of lifestyle on CKD development and to provide data for preventing the onset and progression of CKD.

KEYWORDS:

Chronic Kidney Disease; Cohort Studies; Lifestyle; Risk Factors

PMID:
30956257
DOI:
10.2188/jea.JE20180220
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