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Neuroimage. 2019 Aug 1;196:16-31. doi: 10.1016/j.neuroimage.2019.03.074. Epub 2019 Apr 4.

Meta-analyses of the n-back working memory task: fMRI evidence of age-related changes in prefrontal cortex involvement across the adult lifespan.

Author information

1
Centre for Cognition and Decision Making, National Research University Higher School of Economics, Moscow, Russian Federation; Department of Psychology, National University of Singapore, Singapore.
2
Department of Psychology, York University, Toronto, Canada.
3
Department of Psychology, York University, Toronto, Canada; NeuropsyLab, Department of Psychology, National Research University Higher School of Economics, Moscow, Russian Federation. Electronic address: marie.arsalidou@gmail.com.

Abstract

Working memory, a fundamental cognitive function that is highly dependent on the integrity of the prefrontal cortex, is known to show age-related decline across the typical healthy adult lifespan. Moreover, we know from work in neurophysiology that the prefrontal cortex is disproportionately susceptibly to the pathological effects of aging. The n-back task is arguably the most ubiquitous cognitive task for investigating working memory performance. Many functional magnetic resonance imaging (fMRI) studies examine brain regions engaged during performance of the n-back task in adults. The current meta-analyses are the first to examine concordance and age-related changes across the healthy adult lifespan in brain areas engaged when performing the n-back task. We compile data from eligible fMRI articles that report stereotaxic coordinates of brain activity from healthy adults in three age-groups: young (23.57 ± 5.63 years), middle-aged (38.13 ± 5.63 years) and older (66.86 ± 5.70 years) adults. Findings show that the three groups share concordance in the engagement of parietal and cingulate cortices, which have been consistently identified as core areas involved in working memory; as well as the insula, claustrum, and cerebellum, which have not been highlighted as areas involved in working memory. Critically, prefrontal cortex engagement is concordant for young, to a lesser degree for middle-aged adults, and absent in older adults, suggesting a gradual linear decline in concordance of prefrontal cortex engagement. Our results provide important new knowledge for improving methodology and theories of cognition across the lifespan.

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