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Semin Cell Dev Biol. 2019 Apr 9. pii: S1084-9521(18)30091-0. doi: 10.1016/j.semcdb.2019.03.012. [Epub ahead of print]

Microglia immunometabolism: From metabolic disorders to single cell metabolism.

Author information

1
Department of Physiology, University of Lausanne, Rue du Bugnon 7, 1005 Lausanne, Switzerland. Electronic address: rosachiara.paolicelli@unil.ch.
2
School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, 152-160 Pearse Street, D02 R590, Dublin, Ireland. Electronic address: angiaris@tcd.ie.

Abstract

Since the observation that obesity-associated low-grade chronic inflammation is a crucial driver for the onset of systemic metabolic disorders such as type 2 diabetes, a number of studies have highlighted the role of both the innate and the adaptive immune system in such pathologies. Moreover, researchers have recently demonstrated that immune cells can modulate their intracellular metabolic profile to control their activation and effector functions. These discoveries represent the foundations of a research area known as "immunometabolism", an emerging field of investigation that may lead to the development of new-generation therapies for the treatment of inflammatory and metabolic diseases. Most of the studies in the field have focused their attention on both circulating white blood cells and leukocytes residing within metabolic tissues such as adipose tissue, liver and pancreas. However, immunometabolism of immune cells in non-metabolic tissues, including central nervous system microglia, have long been neglected. In this review, we highlight the most recent findings suggesting that microglial cells play a central role in metabolic disorders and that interfering with the metabolic profile of microglia can modulate their functionality and pathogenicity in neurological diseases.

KEYWORDS:

Immunometabolism; Inflammation; Metabolic diseases; Metabolism; Microglia

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