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Lipids Health Dis. 2019 Apr 6;18(1):91. doi: 10.1186/s12944-019-1035-2.

Dietary total fat, fatty acids intake, and risk of cardiovascular disease: a dose-response meta-analysis of cohort studies.

Zhu Y1, Bo Y2,3, Liu Y4.

Author information

1
Department of Cardiology, The first affiliated hospital of Zhengzhou University, Zhengzhou, China.
2
Department of Nutrition, The first affiliated hospital of Zhengzhou University, No. 1 Eastern Jianshe road, Zhengzhou, 450052, Henan, China.
3
Jockey Club School of Public Health and Primary Care, the Chinese University of Hong Kong, Hong Kong, China.
4
Department of Nutrition, The first affiliated hospital of Zhengzhou University, No. 1 Eastern Jianshe road, Zhengzhou, 450052, Henan, China. liuyanhua1015@163.com.

Abstract

BACKGROUND:

Several epidemiological studies have investigated the association between dietary fat intake and cardiovascular disease. However, dietary recommendations based on systematic review and meta-analysis might be more credible.

METHODS AND RESULTS:

Pubmed, Embase and Cochrane library were searched up to July 1st 2018 for cohort studies reporting associations of dietary fat intake and risk of CVDs. By comparing the highest vs. the lowest categories of fat or fatty acids intake, we found that higher dietary trans fatty acids (TFA) intake was associated with increased risk of CVDs [RR:1.14(1.08-1.21)]. However, no association was observed between total fat, monounsaturated fatty acids (MUFA), saturated fatty acids (SFA), and polyunsaturated fatty acids (PUFA), and risk of CVDs. Subgroup analysis found a cardio-protective effect of PUFA in the studies that has been followed up more than 10 years [0.95(0.91-0.99), I2 = 62.4%]. Dose-response analysis suggested that the risk of CVDs increased 16% [1.16 (1.07-1.25), Plinearity = 0.033] for an increment of 2% energy/day of TFA intake.

CONCLUSIONS:

This current meta-analysis of cohort studies suggested that total fat, SFA, MUFA, and PUFA intake were not associated with the risk of cardiovascular disease. However, we found that higher TFA intake is associated with greater risk of CVDs in a dose-response fashion. Furthermore, the subgroup analysis found a cardio-protective effect of PUFA in studies followed up for more than 10 years.

KEYWORDS:

Cardiovascular disease; Dose-response; Fat; Fatty acids; Meta-analysis

PMID:
30954077
PMCID:
PMC6451787
DOI:
10.1186/s12944-019-1035-2
[Indexed for MEDLINE]
Free PMC Article

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