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J Neurol Sci. 2019 May 15;400:148-152. doi: 10.1016/j.jns.2019.03.028. Epub 2019 Mar 29.

Characteristics, survival and incidence rates and trends of pilocytic astrocytoma in children in the United States; SEER-based analysis.

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Christian Hospital Quakenbrück, Academic Teaching Hospital of the University of Oldenburg, 49610 Quakenbrück, Germany. Electronic address:



Pilocytic astrocytoma (PA) is a neurological neoplasm and a common neurological tumor among children. No recent reports have studied the recent demographic characteristics of PA cases in the US.


We used the Surveillance, Epidemiology, and End Results (SEER) Program to retrieve data on children diagnosed with PA between 2000 and 2015. We calculated the incidence, annual percentage changes (APC), and survival.


Our study included 3084 children with PA, with an incidence of 8.227 per 1,000,000 person-years, being highest among whites (9.062), and children aged 1-4 year (11.175). Overall incidence in children increased significantly over the study period, with an APC of 0.825% (95% CI[0.027-1.630], P = .044). Moreover, incidence among blacks increased significantly over the study period (APC = 3.466%, 95% CI[0.342-6.688], P = .032), but did not change among other races. The relative 5-year survival of included patients was 95.3%, with patients younger than 1 year having the worst survival.


Overall PA incidence and incidence among blacks has been increasing last decade. Additionally, PA survival was found to be worse among infants. Further studies are also needed to investigate the effect of the age and race on the incidence and survival of PA.


Children; Pilocytic astrocytoma; SEER program; Survival; United States


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