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J Microbiol Methods. 2019 May;160:104-106. doi: 10.1016/j.mimet.2019.04.002. Epub 2019 Apr 3.

Insufficient sensitivity of laser desorption-time of flight mass spectrometry-based detection of hemozoin for malaria screening.

Author information

1
Department of Medical Microbiology, Virology and Hygiene, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
2
Department of Microbiology and Hospital Hygiene, Bundeswehr Hospital Hamburg, Hamburg, Germany; Institute for Medical Microbiology, Virology and Hygiene, University Medicine Rostock, Rostock, Germany. Electronic address: frickmann@bnitm.de.
3
Bernhard Nocht Institute for Tropical Medicine Hamburg, Hamburg, Germany.
4
Swiss Tropical and Public Health Institute, Basel, Switzerland; Faculty of Medicine, University Basel, Basel, Switzerland.

Abstract

Laser desorption-time of flight (LD-TOF) mass spectrometry-based detection of hemozoin was assessed for its performance characteristics as a rapid screening test for malaria. In spite of good specificity of >95%, poor sensitivity of 80.2% for microscopically positive samples makes the easy-to-apply and rapid approach unsuitable for the routine diagnostic setting.

KEYWORDS:

LD-TOF; Malaria; Mass spectrometry; Plasmodium; Rapid diagnostic test; Tropics

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