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Mol Brain. 2019 Apr 5;12(1):32. doi: 10.1186/s13041-019-0454-3.

Overexpression of activated CaMKII in the CA1 hippocampus impairs context discrimination, but not contextual conditioning.

Author information

1
School of Biological Sciences, Seoul National University, Gwanak-gu, Seoul, 08826, South Korea.
2
School of Biological Sciences, Seoul National University, Gwanak-gu, Seoul, 08826, South Korea. kaang@snu.ac.kr.

Abstract

Calcium/Calmodulin-dependent protein kinase II (CaMKII) plays a key role in the molecular mechanism of memory formation. CaMKII is known to be activated specifically in the activated spines during memory formation. However, it is unclear whether the specific activation of CaMKII is necessary for encoding information. Here, we overexpressed active form of CaMKII (CaMKII*) in the hippocampal CA1 region to activate CaMKII nonspecifically. Moreover, we examined context-discrimination performance of mice. We found that the mice with overexpression of CaMKII* showed impaired context-discrimination ability, while the contextual fear conditioning remained intact. These results indicate that spatial specificity of CaMKII activation is necessary for context discrimination.

KEYWORDS:

CaMKII; Context discrimination; Contextual fear conditioning; Hippocampus; Memory

PMID:
30953515
PMCID:
PMC6449978
DOI:
10.1186/s13041-019-0454-3
[Indexed for MEDLINE]
Free PMC Article

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