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J Gastrointest Cancer. 2019 Apr 6. doi: 10.1007/s12029-019-00231-y. [Epub ahead of print]

The Unusual Suspects of the Pancreas-Understanding Pancreatic Acinar Cell Carcinomas and Adenomas.

Author information

1
Department of General and Visceral Surgery, St. Josef-Hospital, University Hospital, Ruhr-University Bochum, Gudrunstrasse 56, 44791, Bochum, Germany.
2
Department of General and Visceral Surgery, St. Josef-Hospital, University Hospital, Ruhr-University Bochum, Gudrunstrasse 56, 44791, Bochum, Germany. t.fahlbusch@klinikum-bochum.de.
3
Department of Pathology, Berufsgenossenschaftliches Universit├Ątsklinikum Bergmannsheil, Ruhr-University Bochum, B├╝rkle de la Camp Platz 1, 44789, Bochum, Germany.

Abstract

PURPOSE:

Acinar cell carcinomas (ACC) and adenomas (ACA) of the pancreas are rare entities. Sufficient knowledge about occurrence and prognosis is scarce.

METHODS:

A retrospective chart review of our database was performed for all patients who had undergone pancreatic surgery between 2006 and 2018. Results were compared to recent literature findings.

RESULTS:

Nine patients were diagnosed with ACC and four patients with ACA of the pancreas in the study period. ACC patients were older and more often male than patients of the ACA group. ACC were mainly localized in the pancreatic head, whereas ACA were more often found in the distal pancreas. Tumor markers are not necessarily elevated, even in case of malignancy.

CONCLUSIONS:

ACC and ACA are very rare pancreatic tumors. Both entities account for less than 1% of all pancreatic neoplasms. Diagnosis is challenging due to unspecific radiologic features and clinical symptoms. Nevertheless, a patient complaining of abdominal discomfort and an unclear hypodense pancreatic lesion should undergo surgical exploration.

KEYWORDS:

Acinar cell adenoma; Acinar cell carcinoma; Pancreatic carcinoma; Pancreatic surgery; Pancreatic tumor

PMID:
30953241
DOI:
10.1007/s12029-019-00231-y

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