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Anticancer Res. 2019 Apr;39(4):2025-2033. doi: 10.21873/anticanres.13313.

Prognostic Roles of SCC Antigen, CRP and CYFRA 21-1 in Oral Cavity Squamous Cell Carcinoma.

Author information

1
Department of Otolaryngology - Head & Neck Surgery, Chang Gung Memorial Hospital, Taoyuan, Taiwan, R.O.C.
2
Department of Head and Neck Surgery, San Pedro University, San Pedro, Peru.
3
Department of Otolaryngology, Chang Gung Memorial Hospital, Keelung, Taiwan, R.O.C.
4
Department of Public Health, Chang Gung University, Taoyuan, Taiwan, R.O.C.
5
Department of Nutrition and Health Sciences, Chang Gung University of Science and Technology, Taoyuan, Taiwan, R.O.C.
6
Plastic and Reconstructive Surgery, Chang Gung Memorial Hospital, Linkou, Taiwan, R.O.C.
7
Medical College, Chang Gung University, Taoyuan, Taiwan, R.O.C.
8
Department of Radiation Oncology, Chang Gung Memorial Hospital, Chang Gung University, Taoyuan, Taiwan, R.O.C.
9
Department of Medical Oncology, Chang Gung Memorial Hospital, Chang Gung University, Taoyuan, Taiwan, R.O.C.
10
Department of Otolaryngology - Head & Neck Surgery, Chang Gung Memorial Hospital, Taoyuan, Taiwan, R.O.C. bigmac@adm.cgmh.org.tw.

Abstract

BACKGROUND/AIM:

Tumor-related and inflammation-related markers were reported to be prognostic in cancer patients. In this study, we evaluated squamous cell carcinoma antigen (SCC-Ag), cytokeratin 19 fragment (CYFRA 21-1) and C-reactive protein (CRP) simultaneously in oral cavity squamous cell carcinoma (OSCC) patients.

PATIENTS AND METHODS:

Two hundred and forty-six newly diagnosed OSCC patients were retrospectively recruited between December 2010 and December 2016.

RESULTS:

The elevation of CRP levels (≥5.0 mg/l) and SCC-Ag levels (≥2.0 ng/ml) were significantly related with tumor invasion parameters and metastatic factors. In contrast, the elevation of CYFRA 21-1 levels (≥3.3 ng/ml) was related with extranodal extension alone. For patients with all three markers being elevated before surgery, their overall survival and disease-free survival were significantly worse than others.

CONCLUSION:

Concurrent elevation of preoperative SCC-Ag, CYFRA 21-1 and CRP serum levels can be correlated with worse survival rates in OSCC.

KEYWORDS:

C-reactive protein; CYFRA 21-1; Oral cavity; SCC antigen; prognosis; squamous cell carcinoma

PMID:
30952746
DOI:
10.21873/anticanres.13313
[Indexed for MEDLINE]

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