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Cell. 2019 Apr 4;177(2):231-242. doi: 10.1016/j.cell.2019.03.023.

The Extracellular RNA Communication Consortium: Establishing Foundational Knowledge and Technologies for Extracellular RNA Research.

Collaborators (139)

Abdel-Mageed AB, Adamidi C, Adelson PD, Akat KM, Alsop E, Ansel KM, Arango J, Aronin N, Avsaroglu SK, Azizian A, Balaj L, Ben-Dov IZ, Bertram K, Bitzer M, Blelloch R, Bogardus KA, Breakefield XO, Calin GA, Carter BS, Charest A, Chen CC, Chitnis T, Coffey RJ, Courtright-Lim A, Das S, Datta A, DeHoff P, Diacovo TG, Erle DJ, Etheridge A, Ferrer M, Franklin JL, Freedman JE, Galas DJ, Galeev T, Gandhi R, Garcia A, Gerstein MB, Ghai V, Ghiran IC, Giraldez MD, Goga A, Gogakos T, Goilav B, Gould SJ, Guo P, Gupta M, Hochberg F, Huang B, Huentelman M, Hunter C, Hutchins E, Jackson AR, Kalani MYS, Kanlikilicer P, Karaszti RA, Van Keuren-Jensen K, Khvorova A, Kim Y, Kim H, Kim TK, Kitchen R, Kraig RP, Krichevsky AM, Kwong RY, Laurent LC, Lee M, L'Etoile N, Levy SE, Li F, Li J, Li X, Lopez-Berestein G, Lucero R, Mateescu B, Matin AC, Max KEA, McManus MT, Mempel TR, Meyer C, Milosavljevic A, Mondal D, Mukamal KJ, Murillo OD, Muthukumar T, Nickerson DA, O'Donnell CJ, Patel DJ, Patel T, Patton JG, Paul A, Peskind ER, Phelps MA, Putterman C, Quesenberry PJ, Quinn JF, Raffai RL, Ranabothu S, Rao SJ, Rodriguez-Aguayo C, Rosenzweig A, Roth ME, Rozowsky J, Sabatine MS, Sakhanenko NA, Saugstad JA, Schmittgen TD, Shah N, Shah R, Shedden K, Shi J, Sood AK, Sopeyin A, Spengler RM, Spetzler R, Srinivasan S, Subramanian SL, Suthanthiran M, Tanriverdi K, Teng Y, Tewari M, Thistlethwaite W, Tuschl T, Urbanowicz KK, Vickers KC, Voinnet O, Wang K, Weaver AM, Wei Z, Weiner HL, Weiss ZR, Williams Z, Wong DTW, Woodruff PG, Xiao X, Yan IK, Yeri A, Zhang B, Zhang HG.

Author information

1
Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA 02114, USA.
2
http://exRNA.org/.
3
Department Microbiology & Immunology and Sandler Asthma Basic Research Center, University of California San Francisco, San Francisco, CA 94143, USA.
4
Department of Medicine, University of Michigan, Ann Arbor, MI 48109, USA.
5
Department of Neurology and Center for Molecular Imaging Research Department of Radiology, Massachusetts General Hospital, Charlestown, MA 02129 USA; Program in Neuroscience, Harvard Medical School, Boston, MA 02115, USA.
6
Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
7
Pacific Northwest Research Institute, Seattle, WA 98122, USA.
8
Program in Computational Biology & Bioinformatics, Department of Molecular Biophysics & Biochemistry, Department of Computer Science, and Department of Statistics & Data Science, Yale University, New Haven, CT 06520, USA.
9
Department of Neurosurgery, University of California, San Diego, CA 92093, USA.
10
Molecular and Human Genetics Department, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77030, USA; Program in Quantitative and Computational Biosciences, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77030, USA.
11
Department of Microbiology and Immunology, University of California San Francisco Diabetes Center, WM Keck Center for Noncoding RNAs, University of California, San Francisco, San Francisco, CA 94143, USA.
12
Department of Transplantation, Mayo Clinic, Jacksonville, FL 32224, USA.
13
Department of Surgery, University of California San Francisco & Veterans Affairs Medical Center San Francisco, San Francisco, CA 94121, USA.
14
Department of Molecular Biophysics and Biochemistry, Program in Computational Biology and Bioinformatics, Yale University, New Haven, CT 06520, USA.
15
Department of Anesthesiology & Perioperative Medicine, Oregon Health & Science University, Portland, OR 97239, USA.
16
Neurogenomics, Translational Genomics Research Institute, Phoenix, AZ 85284, USA.
17
Department of Cell and Developmental Biology, Vanderbilt University School of Medicine and Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
18
Department of Obstetrics, Gynecology, and Reproductive Sciences and Sanford Consortium for Regenerative Medicine, University of California, San Diego, La Jolla, CA 92093, USA. Electronic address: llaurent@ucsd.edu.

Abstract

The Extracellular RNA Communication Consortium (ERCC) was launched to accelerate progress in the new field of extracellular RNA (exRNA) biology and to establish whether exRNAs and their carriers, including extracellular vesicles (EVs), can mediate intercellular communication and be utilized for clinical applications. Phase 1 of the ERCC focused on exRNA/EV biogenesis and function, discovery of exRNA biomarkers, development of exRNA/EV-based therapeutics, and construction of a robust set of reference exRNA profiles for a variety of biofluids. Here, we present progress by ERCC investigators in these areas, and we discuss collaborative projects directed at development of robust methods for EV/exRNA isolation and analysis and tools for sharing and computational analysis of exRNA profiling data.

PMID:
30951667
PMCID:
PMC6601620
[Available on 2020-04-04]
DOI:
10.1016/j.cell.2019.03.023

Publication type, Grant support

Publication type

Grant support

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