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WHO South East Asia J Public Health. 2019 Apr;8(1):42-49. doi: 10.4103/2224-3151.255349.

Prescribing, dispensing and administration indicators to describe rational use of oral dosage forms of medicines given to children.

Author information

1
Department of Allied Health Sciences, Faculty of Medical Sciences, University of Sri Jayewardenepura, Sri Lanka.
2
Department of Paediatrics, Faculty of Medicine, University of Jaffna, Sri Lanka.
3
Department of Public Health, Faculty of Medicine, University of Kelaniya, Sri Lanka.
4
Department of Pharmacology, Faculty of Medicine, University of Colombo, Sri Lanka.

Abstract

Background:

Owing to lack of indicators, researchers are compelled to use non-specific indicators to assess rational use of medicines in children. Thus, paediatric-specific issues are poorly described. This study aims to develop a set of indicators to describe rational use of oral dosage forms of medicines given to children.

Methods:

A modified RAND/UCLA Appropriateness Method was used. A comprehensive draft list of 40 indicators was compiled, based on the results of a literature review. Twelve experts rated these indicators in two rounds, using a nine-point Likert scale, first in an online survey, for clarity, necessity and scientific merit, and secondly in a face-to-face meeting, for necessity, feasibility and predictive value. An overall panel median score of ≥7 and agreement within the experts were used in indicators. The indicators were ranked independently by the research team and a final list of indicators was prepared. These indicators were pilot-tested for acceptability and interrater reliability.

Results:

Nine prescribing indicators, such as weight, appropriate dose and age-appropriate dosage form; five dispensing indicators, such as adequacy of labelling and inappropriate manipulation by pharmacists; and five administration indicators, such as inappropriate manipulation by parents and full completion of dose, were finalized in the second round.

Conclusion:

This novel approach has provided a set of indicators to describe the use of oral dosage forms of medicines given to children, which can be used by researchers as a supplement to the World Health Organization's drug use indicators when investigating rational use of medicines in children.

KEYWORDS:

children; indicators; medicines; oral dosage forms; rational use

PMID:
30950430
DOI:
10.4103/2224-3151.255349
[Indexed for MEDLINE]
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