Format

Send to

Choose Destination
Mater Sci Eng C Mater Biol Appl. 2019 Jul;100:855-861. doi: 10.1016/j.msec.2019.03.028. Epub 2019 Mar 9.

Formation of enzymatic/redox-switching nanogates on mesoporous silica nanoparticles for anticancer drug delivery.

Author information

1
The Key Laboratory for Ultrafine Materials of Ministry of Education, State Key Laboratory of Bioreactor Engineering and Engineering Research Centre for Biomedical Materials of Ministry of Education, East China University of Science and Technology, Shanghai 200237, China.
2
Ministry-of-Education Key Laboratory for the Green Preparation and Application of Functional Materials, College of Chemistry and Chemical Engineering, Hubei University, Wuhan 430062, China.
3
The Key Laboratory for Ultrafine Materials of Ministry of Education, State Key Laboratory of Bioreactor Engineering and Engineering Research Centre for Biomedical Materials of Ministry of Education, East China University of Science and Technology, Shanghai 200237, China. Electronic address: yulinli@ecust.edu.cn.
4
The Key Laboratory for Ultrafine Materials of Ministry of Education, State Key Laboratory of Bioreactor Engineering and Engineering Research Centre for Biomedical Materials of Ministry of Education, East China University of Science and Technology, Shanghai 200237, China. Electronic address: liucs@ecust.edu.cn.

Abstract

In this study, we demonstrate a simple approach to developing mesoporous nanohybrids via a process of pre-loading of an anticancer drug (doxorubicin, DOX) into mesoporous silica nanoparticles (MSN), followed by assembly with a kind of naturally-derived polymer (gelatin, cleavable by matrix metalloproteinase 2 overexpressed by tumor). The gelatin shell is then in situ crosslinked by degradable N,N'-bis(acryloyl)cystamine (BAC) to form enzymatic and redox switchable nanogates on the mesoporous nanoparticles. The nanohybrids displayed pH/redox/enzymatic sensitivity in DOX release under conditions mimicking tumor microenvironments. The nanocarriers can be effectively taken up by A549 cells (a carcinomic human alveolar basal epithelial cell line), resulting in a high DOX intracellular accumulation and an improved anticancer cytotoxicity when compared with free DOX, suggesting their potential as a nanoplatform for therapeutic delivery.

KEYWORDS:

Anticancer drug delivery; Gelatin; MMP 2 cleavable; Mesoporous nanoparticles; Nanogate

PMID:
30948123
DOI:
10.1016/j.msec.2019.03.028

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center